Perlson lab @LabPerlson
🔬 Molecular Neurodegeneration research group at Tel Aviv University, Israel www3.tau.ac.il/medicine/perls… Tel Aviv, Israel Joined February 2019-
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TARDBP (TDP-43) Knock-in Zebrafish Display a Late-Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons onlinelibrary.wiley.com/doi/10.1002/an…
Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation: Cell cell.com/cell/fulltext/…
Activation of polo-like kinase 1 correlates with selective motor neuron vulnerability in familial ALS: Cell Reports cell.com/cell-reports/f…
An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALS: biorxiv.org/content/10.110…
Incredible place to live and work! Plus you get to be UF colleagues as well!! BONUS 😍
Incredible place to live and work! Plus you get to be UF colleagues as well!! BONUS 😍
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes: nature.com/articles/s4159…
Happy to share our community note published in Nature Communications. In this 14-page article (34 authors from 9 countries), we discuss current practices in biomolecular phase separation and hope it will be useful to the biomolecular condensate community. nature.com/articles/s4146…
Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial: nature.com/articles/s4146…
Cortical hyperexcitability drives dying forward amyotrophic lateral sclerosis symptoms and pathology in mice: sciencedirect.com/science/articl…
Embryonic motor neuron programming factors reactivate immature gene expression and suppress ALS pathologies in postnatal motor neurons nature.com/articles/s4159…
Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons nature.com/articles/s4146…
High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs: nature.com/articles/s4155…
Researchers discover that a high-fat diet damages the heart in mice by disrupting metabolism in heart cells called cardiomyocytes but find that knocking out the enzyme PTP1B can prevent these harmful effects. @scisignal scim.ag/470PfGG
Skeletal muscle TDP-43 aggregation drives progressive motor dysfunction and neurodegeneration with potential for functional recovery ... biorxiv.org/content/10.110… #biorxiv_neursci
Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures cell.com/neuron/fulltex…
Small-molecule dissolution of stress granules by redox modulation benefits ALS models nature.com/articles/s4158…
Proteomics Analysis of the TDP- 43 Interactome in Cellular Models of ALS Pathogenesis onlinelibrary.wiley.com/doi/10.1111/jn…
Intramuscular Nerve Bundles Reflect TDP‐43 Pathology in the Medulla and Spinal Cord of ALS Patients pmc.ncbi.nlm.nih.gov/articles/PMC11…
Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease: nature.com/articles/s4358…
Check out our @Nature review with Tiannan Guo @guomics and Judith Steen @ionicwoman on recent paradigm shifts in MS-based proteomics - where the field stands and where its headed. #Proteomics #AI nature.com/articles/s4158…

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