Neural Cell News @NeuralCell
An online resource for the neuroscience research community. Part of the @STEMCELLTech Science News service. neuralcellnews.com Joined June 2010-
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Researchers, including Drs. Manuel Valero & György Buzsáki, reveal a fundamental role for the cooperative function of interneuron families in the emergence of the hippocampal cognitive map. 🧠 🗺️ Check out their recent study in @ScienceMagazine! bit.ly/41AD1kP
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Collaborators ed by Drs. Gopal Thinakaran and Jubao Duan elucidate the selective late-onset #AlzheimersDisease vulnerability in microglia at the PICALM locus through detrimental lipid droplet accumulation. 💧 @Nature | go.nature.com/3JQaH7
Dr. David Gutmann and team discovered that glutamate receptor stimulation phosphorylates sarcoma proto-oncogene to activate platelet-derived growth factor receptor-α-dependent extracellular-regulated kinase signaling and drive #glioma growth. 💡 bit.ly/4g5orYl
Collaborators, including Drs. Akira Sawa and Bert Brône, show that cytoskeletal control in adult microglia is essential to restore neurodevelopmental synaptic and cognitive deficits. 🧠 @ScienceAdvances | bit.ly/3UXewdS
Dr. Raymond Swanson's team shows that superoxide enters neurons through volume-regulated anion channels (VRACs). Superoxide entry through VRACs is a requisite step in excitotoxic neuronal injury. 🧠 bit.ly/3JVWx56
Researchers alongside Dr. Laure Bally-Cuif at @institutpasteur show that NSCs are divided into subpopulations, some of which quickly respond to Notch pathway inhibition, while others exhibit moderate to no response and a delay to enter the cell cycle. bit.ly/45RmURa
Dr. @JimSkeath and team identified glia as the primary site of disease progression in HLD-18 and may inform on juvenile forms of #ALS, which also feature elevated dihydroceramide levels. @eLife | bit.ly/3VlbyzY
How does a microglial gene affect neuronal homeostasis? The Green lab shows that β-hexosaminidase is secreted by microglia and integrated into the lysosomal compartment of neurons. 🧠 👉 go.nature.com/4lKr6It
Too much excitement can be toxic! ☠️ Dr. David Julius and team show that electron transport chain (ETC) is a major determinant of resilience to excitotoxicity. Reducing oxidative stress and calcium entry underlie this protective mechanism. bit.ly/3HvI8vX
Dr. Ana Andreazza and team utilized iPSC-derived cerebral organoids from #BipolarDisorder patients and healthy controls to model disease-specific metabolic and inflammatory dysfunction in a more physiologically relevant system. 💡 go.nature.com/45PoXoD
Scientists identified ubiquitin-specific protease 7 as a nuclear regulator of O6-methylguanine-DNA-methyltransferase stability and temozolomide resistance. 💊 go.nature.com/45M9wOk
The @VilledaLab identified ferritin light chain 1 (FTL1) as a pro-aging neuronal factor that impairs cognition. They detected an increase in neuronal FTL1 in the hippocampus of aged mice, which correlated with cognitive decline. 👉 go.nature.com/3JpKgG1
Out now in @Nature! Collaborators, including Drs. @ciaranscotthill and Simona Parrinello, identify axonal injury as a key driver of #glioblastoma progression, which is induced in white matter by early tumor cells preferentially expanding in this region. 🔓…
In this new @Cancer_Cell study, researchers reveal the complexity of neuron-glioma connectivity, highlighting long-range neuromodulatory pathways as promising therapeutic targets in #glioblastoma. 🕳️ Dig into more details: bit.ly/4ozAuB8
Gain insights about cerebellar morphogenesis regulation! Dr. James Li's team show that Foxp1 and Foxp2 regulate Purkinje cell-subtype differentiation, with disruptions in these genes leading to altered cerebellar patterning. 🧠 @NatureNeuro | go.nature.com/4lz3beS
Get to know TP63 as a modulator of ferroptosis in TP53 mutations #glioblastoma. 📖 Read the full story in @cddpress: go.nature.com/4fCinX8
Neural Cell News retweeted
My lab is hiring multiple PhD students and postdoctoral fellows. If you are in Canada and interested in neuroscience, regenerative medicine and stem cells, contact me. We are a productive group working on pathogenesis and treatment of multiple sclerosis. lnkd.in/eD3fkrp4is
🐀 Researchers with Dr. @Jess_Chadwick at @imperialcollege found that in mice, in contrast to a neuropathy-inducing high-fat diet that causes leptin resistance, intermittent fasting enhances leptin sensitivity in dorsal root ganglia sensory neurons. @NeuroCellPress |…
Fudan University scientists show that grafted A10-like midbrain dopaminergic neurons can reconstruct specific circuits and functionally restore impaired circuits. 🔌 🧠 bit.ly/47u8Xeh
Take a closer look at the dynamics of meningeal adaptive immunity. 👀 Researchers analyzed the meninges of aged wild-type mice and mouse models of early-onset #AlzheimersDisease, tauopathy, and Down syndrome-related #neurodegenerative disorders. bit.ly/45NYOYA
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Esak (Isaac) Lee @IsaacLeeLab
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Merylin Ogunlola🐰�... @merylin_neuro
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2K Followers 4K Following Neuroscientist and cancer biologist. Scientific Director at @fapergs. Full Professor of Pharmacology @ufrgsnoticias. Wannabe cook and bass player
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