Leon Smyth @lcdsmyth
Neuroimmunology, meningeal stroma, and barriers 🦠 🧠 | Group Leader @MonashUni | former @kipnislab @wustl postdoc St Louis Joined April 2023-
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1/ Thrilled to share that my PhD thesis work is now out in its final form @Nature! A huge thanks to the entire team (which has only grown since we first put this out), our peer reviewers, the Nature editorial team, and the incredible @Molofsky_lab. nature.com/articles/s4158…
1/ Thrilled to share that my PhD thesis work is now out in its final form @Nature! A huge thanks to the entire team (which has only grown since we first put this out), our peer reviewers, the Nature editorial team, and the incredible @Molofsky_lab. nature.com/articles/s4158…
I'm excited that @Jjiyeon_lee's 2nd paper from the lab is out in @NatureAging. We found that the circadian gene REV-ERBalpha regulates brain NAD+ by controlling CD38 in astrocytes. REV-ERB KO or pharmacologic inhibition mitigates tau pathology in mice. nature.com/articles/s4358…
New from the @HelkerLab! 👏 @lukas_herdt and co-authors uncover a meningeal-vascular signaling axis that promotes fenestrated vessel formation in the choroid plexus and is essential for establishing cerebrovascular heterogeneity. 🚦 go.nature.com/3HLm0gZ | @NatureComms
Dural ectopic lymphatic structures accumulate during aging and exhibit dysregulation in neurodegenerative diseases | PNAS pnas.org/doi/10.1073/pn…
We have 2 positions available for talented bioinformaticians to join our team at CCB! Experience in analysis of transcriptomic datasets an advantage! Details👇 University Of South Australia - Research Associate/Research Fellow (Level ARAS / Level BRF) workingatunisa.nga.net.au/cp/index.cfm?e…
Not only a nice article about our recent work in @CellCellPress but also I was upgraded from PhD to MD... I shall request salary update too 😂
Not only a nice article about our recent work in @CellCellPress but also I was upgraded from PhD to MD... I shall request salary update too 😂
Nightclubs have bouncers — so does your brain. Neuroimmunology research led by Jonathan Kipnis, MD, reveals tiny mast cells guard brain fluid‑draining gates, blocking pathogens and opening entirely new avenues to prevent infection. medicine.washu.edu/news/immune-bo…
Excited to share this new work from our lab, led by an exceptional graduate student, Tornike Mamuladze (@tornikemamu), on the role of meningeal mast cells in regulation of brain/dura access points, with implications to CSF flow dynamics and meningitis || authors.elsevier.com/sd/article/S00…
Now online! Mast cells regulate the brain-dura interface and CSF dynamics dlvr.it/TM5sBD
Mast cells regulate the brain-dura interface and CSF dynamics: Cell cell.com/cell/fulltext/…
Bittersweet feeling to say goodbye and bon voyage to @gao_wenqing and to wish her the best of luck as she starts her new lab @hkust! This is the third postdoc this year to open their own lab! We miss Wenqing already!
Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity nature.com/articles/s4159…
Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity @NatImmunol @TheColonnaLab @DuSiling nature.com/articles/s4159… nature.com/articles/s4159…
Our new study by @DuSiling reveals how CSF1R mutations in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) disrupt glial homeostasis. Key roles for oligodendrocytes, astrocytes & STAT3 signaling. nature.com/articles/s4159…
🧵1/ Excited to share my first publication from the @ColonnaLab in @NatImmunol! We investigated how mutations in the human CSF1R gene disrupt microglia and impair white matter integrity in a rare but devastating neurodegeneration called ALSP. nature.com/articles/s4159…
Celebrating acceptance of a beautiful and important story! Congratulations, @tmamuladze! More details to come soon! 👏👏
Congrats to Prof Laura Mackay (@UniMelb & @TheDohertyInst) who was awarded the 2024 NHMRC Elizabeth Blackburn Investigator Grant Award (Leadership in Basic Science). Her groundbreaking immunotherapy research is paving the way for better immune protection and patient outcomes
Review @ImmunityCP @jonykipnis @mitchkim_mw Glymphatics and meningeal lymphatics unlock the brain-immune code cell.com/immunity/fullt…
Review @ImmunityCP Niche-specific therapeutic targeting of myeloid cells in the central nervous system cell.com/immunity/fullt…
Review @ImmunityCP @MovahediTeam Border-associated macrophages as gatekeepers of brain homeostasis and immunity cell.com/immunity/fullt…

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