Patrick Pfaff @nullfear04
Postdoctoral Fellow @kevansf @UCSF | PhD @CarreiraGroup @ETH San Francisco, CA Joined August 2014-
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We are excited to report a series of covalent inhibitors for K-Ras(G12D) based on a ring-opening alkylation mechanism of malolactones. nature.com/articles/s4158…
Incredibly honored to receive this recognition of our lab’s work on KRAS(G12C) especially @JonathanOstrem and Ulf Peters who teamed up to drug the undruggable. Thanks @frankpmccormick for introducing me to the beating heart of cancer. @UCSFCancer @HHMINEWS @KRASKickers
Incredibly honored to receive this recognition of our lab’s work on KRAS(G12C) especially @JonathanOstrem and Ulf Peters who teamed up to drug the undruggable. Thanks @frankpmccormick for introducing me to the beating heart of cancer. @UCSFCancer @HHMINEWS @KRASKickers
Great to have @dynlacht @nyulangone visit @kevansf @UCSF group for a sabbatical! Exciting times with 3D structures and team benchwork thinking about new cancer targets. #cancer #cellbio #drugdiscovery #cytoskeleton @nullfear04 @UCSFCancer @QBI_UCSF @Perlmutter_CC
Join us in congratulating former group member @RomanSarott and current postdoc @StanfordUChem on receiving the 2022 ElSohly Award!! Together with @AditiDa38734987 and Federica Pellati, they will present their work at the ACS Meeting in San Diego in March. prnewswire.com/news-releases/…
Total Synthesis of Shearinines D and G featuring an intramolecular Rh-catalyzed cyclopropanation to furnish a trans-hydrindane out now in @angew_chem 🥳🧪Congratulations to @nicolehauser15, Michael Imhof and everyone involved in this project. onlinelibrary.wiley.com/doi/10.1002/an…
OPEN ACCESS 🔓 + one of our most read articles in the last 30 days: Azoacetylenes for the Synthesis of Arylazotriazole Photoswitches by @nullfear04, Anderl, Fink, @MBlknhl @CarreiraGroup @ETH_en fal.cn/3j23Y
Super excited to share our newest preprint on developing a BRD4-selective degrader with the project spearheaded by @adivkrn chemrxiv.org/engage/chemrxi…
The Bhawal Lab is up and running! A warm welcome to @lisatwurls who joins us for her Master's project @EdinburghChem
Milestone day for the Nabet lab - we are officially open @fredhutch!! Incredibly grateful for the support of so many colleagues, friends and family for making this day possible. We couldn't be more excited to get started. Let's go!!
Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation pubs.acs.org/doi/10.1021/ja…
Our latest work on azopyrazoles in @J_A_C_S. Interested in switching using echem and/or in films? Check it out! Spectacular work by @JakeyLG and Mike and in collaboration in the amazing @GraceGDHan. @impchemistry @BrandeisU
Our latest work on azopyrazoles in @J_A_C_S. Interested in switching using echem and/or in films? Check it out! Spectacular work by @JakeyLG and Mike and in collaboration in the amazing @GraceGDHan. @impchemistry @BrandeisU
Prior to the pandemic Jack Dunitz in his late 90s routinely came to @ETH_DCHAB and interacted with other scientists. He was very close to our group and me both personally and professionally - he will be dearly missed.
Prior to the pandemic Jack Dunitz in his late 90s routinely came to @ETH_DCHAB and interacted with other scientists. He was very close to our group and me both personally and professionally - he will be dearly missed.
Excited to announce an incredible lineup for Photopharmacology III. Our website is live, please sign up (it's for free) and submit a poster. Please RT and spread the news! event.fourwaves.com/photopharmacol…… @photopharma_lit @MolSwitches @nyuchemistry @chemuoft #RealTimeChem
Very cool paper in @J_A_C_S by @CarreiraGroup presents masked arylazoacetylenes as orthogonal and #photoswitchable click handles for consecutive #CuAAC bi-conjugation. Of special note is their ability to expeditiously access photo-#PROTACs for BRD4 and AR. pubs.acs.org/doi/10.1021/ja…
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