Happy to share our review on the exciting frontier of covalent chemistry aimed at non-cysteine residues — expanding the toolbox for ligand discovery and chemical biology. Congrats to Gibae Kim from my group!
pubs.acs.org/doi/10.1021/ac…@CovalentMod@UTChemistry@UTAustin
Delightful to see our paper on lysine-selective modifier probes in @CellRepPhysSci made it to the collection of the best chemical biology published so far in CRPS. cell.com/cell-reports-p…
Congratulations to @sonatiwari1212 and others!
Delighted to share one of the first projects of our lab, @sonatiwari1212 applied the HSAB principle on isatoic anhydrides to drive lysine selective modification in proteins, in @CellRepPhysSci@CellPressNews.
Kudos to all, and thanks to @SharathChM!
cell.com/cell-reports-p…
Proteolysis-targeting drug delivery system (ProDDS): integrating targeted protein degradation concepts into formulation design pubs.rsc.org/en/content/art…
For all Macrocycle and Linker afficionados: Check out our perspective recently published in J Med Chem! 📢
The Missing Link(er): A Roadmap to Macrocyclization in Drug Discovery | Journal of Medicinal Chemistry pubs.acs.org/doi/abs/10.102…
Phosphorylation of ACSL4 by mitochondria-located metabolic kinase PCK2 is critical to regulate ferroptosis-associated phospholipid remodeling in tumor repopulating cells that are resistant to chemotherapy and radiotherapy. Read it here rdcu.be/dHOn6
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