Thirupugal Govindarajan, PhD @thirupugal
Scientist working on regenerative cell therapy for cardiomyopathy and muscular dystrophy. linkedin.com/in/thirupugal/ Tucson, Arizona Joined May 2010-
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A new paper in Cell shows that it is possible (simple, really) to convert DNA-editing CRISPR proteins, such as Cas9, into RNA editors. All you have to do is delete a chunk of them. Deleting 55 amino acids from a DNA editor called IscB (the ancestor of Cas9) turned it into a…
‘Sleeping’ cancer cells in the lungs can be roused by COVID and flu nature.com/articles/d4158…
Design of highly functional genome editors by modelling CRISPR–Cas sequences @Nature 1. A groundbreaking study demonstrates the successful design of highly functional CRISPR–Cas genome editors using artificial intelligence, specifically large language models trained on…
Establish a Dedicated Cardiac and Skeletal Muscle Research Subgroup Within The Biophysical Society - Sign the Petition! chng.it/NS2pr6JBXv via @Change
Mice lacking this amino acid lost 30% of their body weight nature.com/articles/d4158…
Another medical milestone! The first patient treated with a prime edited therapeutic shows positive clinical outcomes consistent with effective rescue of his chronic granulomatous disease (CGD), a debilitating and life-shortening primary immunodeficiency. At least 19 base editing…
Pleased to share our newest paper describing a new mechanism for fatty acid transfer between lipid droplets and mitochondria, which is important for regulating fatty acid oxidation. A wonderful team effort and work that I’m extremely proud of. nature.com/articles/s4146…
Female cardiomyocytes show higher expression of fatty acid oxidation genes, leading to greater reliance on fat for energy. A key insight into cardiac sex differences! @Yoshiko96821 @MayaTalukdar ahajournals.org/doi/full/10.11…
Education minister at centre should look at data his own ministry is sharing. Tamil Nadu is the only state where 100% of government schools have digital library. No state even remotely come closer to it. It's too lengthy to write about digital libraries in Tamil Nadu government…
Excited to share our latest article. 7 years ago my then 9 year old son was diagnosed with K210del DCM. With the help of my colleagues @Joseph_C_Wu, @sadayappanlab and Enzo Porrello we identified an FDA approved drug that corrects the mutation. JCI - An FDA-approved drug…
Disrupted recycling of proteins found to damage heart health sciencedaily.com/releases/2025/…
Duchenne muscular dystrophy (DMD) treatment ifetroban led to improvements in measures of heart function in a Phase 2 clinical trial. musculardystrophynews.com/news/phase-2-t…
The science behind the first pig-organ transplant trial in humans nature.com/articles/d4158…
Why I teach my students about scientific failure | Science | AAAS science.org/content/articl…
Introducing mipDVP (multiplexed imaging-powered Deep Visual Proteomics)! Using 22-marker imaging to profile proteomes across hot/cold tumors, revealing immune microenvironments, macrophage barriers to T cells, & hypoxic adaptations. Out in @MolecularCell doi.org/10.1016/j.molc…
Harvard scientists are leaving academia for the private sector to fast-track biomedical breakthroughs. Michael Mina (eMed), Douglas Melton (Vertex), Stuart Schreiber (Arena Bioworks) cite funding delays & admin hurdles as key reasons. #BiomedicalResearch harvardmagazine.com/2025/01/harvar…
Excited to share our new paper in @MolecularCell! We’ve developed TurboCas, a powerful new CRISPR-based proximity labeling tool that lets us pinpoint the proteins regulating gene expression at specific genomic loci. Check out what we discovered: cell.com/molecular-cell…
BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
Spatiotemporal control of neutrophil fate to tune inflammation and repair for myocardial infarction therapy nature.com/articles/s4146…
In vivo CAR T cells move into clinical trials nature.com/articles/d4157…

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