Transcription Factors @AllAboutTFs
I will tweet about TFs: past, present and some future. Tweets are not endorsements. Follow for more TF related science. Nucleus Joined March 2018-
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Are you confused/intrigued about pioneer TFs? Interesting viewpoint discussion on pTFs by the leaders in the field: -What are pTF? -What do they do? -How to study pTF? -Can we classify pTFs? -Are they context dependent? -Does chromatin affect pTF activity? nature.com/articles/s4157…
A de novo transcription-dependent TAD boundary underpins critical multiway interactions during antibody class switch recombination dlvr.it/ShwgTx
Novel TCF7L2 familial linkage and association with Type 2 diabetes, depression, and their comorbidity dlvr.it/ShvXK3
Engineering of Chinese hamster ovary cells for co-overexpressing MYC and XBP1s increased cell proliferation and recombinant EPO production dlvr.it/ShvXJY
CTCF, BEAF-32, and CP190 are not required for the establishment of TADs in early Drosophila embryos but have locus-specific roles dlvr.it/ShvzNb
Job opportunity: Postdoc position in computational biology. To be co-supervised by myself and @fgaiti. There is still time to apply. #epigenetics #Toronto #genomic #computationalscience #cancerevolution nature.com/naturecareers/…
Our new work assessing the role of NR5A2 and ESRRB in early mouse embryos is out: NR5A2 is essential for morula development. biorxiv.org/content/10.110…
We have a postdoc position available. #TEs, #Trophoblast, #Epigenetics qmul.ac.uk/jobs/vacancies…
Excited to share our recent paper on application of our epigenome editing tools to tackle neurodevelopmental disease. A few points we learned are listed below. Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons science.org/doi/10.1126/sc…
Is there any known, published evidence of physical direct interactions between BAF (SWI/SNF) and NuRD?
📢🎉🎊📢 Here is the final version of our study dissecting in vivo, how regulation of Sox2 by its many distal enhancers interplays with CTCF loops throughout development. Led by @ShreetaChakrab1 nature.com/articles/s4158…
1/ We are excited to share some news about human IRF1, which surprisingly turns out to be the key transcription factor downstream from IFN-gamma and STAT1 in macrophages (sciencedirect.com/science/articl…).
Sox2 expression can be regulated across boundaries generated by CTCF-cohesin loops dlvr.it/Shsm9w
How do cell type specific chromatin features affect binding of STAT transcription factors and gene induction during interferon response? Here comes our @TRR179_2 study on that: doi.org/10.26508/lsa.2…
What drives cell type-specific expression differences in the cortex of Alzheimer’s patients? We used single-nucleus multiomics(ATAC+RNA) to link DEGs to candidate CREs and identify TFs that could contribute to altered regulation.🧵 cell.com/cell-genomics/… #singlecell #Alzheimers
In a patient-driven study, we uncover a unique consequence on 3D Pol2 looping at core regulatory TFs in response to BRD4 degradation! mdpi.com/1424-8247/16/2… Thanks to @kaseeedilla and guest editors @ADurbinLab and @JunQiLab, and the talented folks at @CertisOncology
UBC Life Sciences Institute is hiring 6 (!!!) new faculty members! That's right, 6! 100% hard money, great students, fabulous colleagues (like me!), and living in Vancouver. Apply! Check out the ad here lsi.ubc.ca/2023/01/27/six…
Arginine methylation of CEBPA regulates transdifferentiation by a co-factor transposition mechanism. @idpsig, @AllAboutTFs, @MDC_Berlin, @campusbuch, @epigen_papers, @EpigenChromatin biorxiv.org/content/10.110…
Postdoc position available! - Hanna lab (University of Cambridge) - Topic: epigenetics, placental function, pregnancy - Application deadline: 4th November - Link: jobs.cam.ac.uk/job/37346/ @CTR_Cambridge @Cam_Repro
Interesting new insights into TFs and cell fate: Arginine-methylation controls reprogramming speed of a key transcription factor! biorxiv.org/content/10.110… @generegulation @AllAboutTFs @epigenetichulk @CRGenomica @pioneerfactors @MDC_Berlin
Anshul Kundaje (anshu.. @anshulkundaje
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Gene Regulation @generegulation
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TF binding papers �.. @TF_binding_bot
4K Followers 11 Following Papers on transcription factor binding #TFbinding. Maintained by @TeifLab. Also see @nucleosome_bot, @CTCF_papers, @DNAbinding, @cfDNA_papers, @generegulation
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David Suter @davidsuter_epfl
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Nadine Vastenhouw @NVastenhouw
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EPIC_Unit@pasteur @pablonavarroLAB
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Deepak Jha @dkjhaunc
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ReDIB - ICTS @IctsRedib
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なべ@文字起こ�.. @nabesan16857389
80 Followers 659 Following ▼お仕事募集中▼AI&whisperの精度や速度にがっかりしている方へ 講演会や面談音声、弁護士さんへ渡す音声証拠（反訳書）、ポッドキャストに溜まる音声データの文字起こし（テープ起こし）や動画制作が面倒な方へ などなど、お手伝いさせてくださいな。無言フォロー失礼します。お気軽にDMください
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Lijia Li @Lijia2021
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Vittorio Zanzani @v_zanzani
44 Followers 210 Following PhD student in the CBIGR and TOBI labs @UGent @crighent 🧬 bioinformatics - 🗣️ language learning (Italiano/English/Español/Nederlands) - ⛰️🌊 outdoors
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Bardin Lab @bardinlab.. @BardinLab
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TF binding papers �.. @TF_binding_bot
4K Followers 11 Following Papers on transcription factor binding #TFbinding. Maintained by @TeifLab. Also see @nucleosome_bot, @CTCF_papers, @DNAbinding, @cfDNA_papers, @generegulation
Chromatin Haiku @ChromatinHaiku
6K Followers 2K Following Chromatin haiku / To describe and bring alive / DNA, histones
🔥The Levy lab at BGU is hiring🔥 We are looking for new team members (MSc, PhD students and post-docs) excited about chromatin biology, epigenetics and lysine methylation signaling in health and disease. Visit our lab website for more info: lifewp.bgu.ac.il/wp/ledan/ Please RT.
A de novo transcription-dependent TAD boundary underpins critical multiway interactions during antibody class switch recombination dlvr.it/ShwgTx
Engineering of Chinese hamster ovary cells for co-overexpressing MYC and XBP1s increased cell proliferation and recombinant EPO production dlvr.it/ShvXJY
CTCF, BEAF-32, and CP190 are not required for the establishment of TADs in early Drosophila embryos but have locus-specific roles dlvr.it/ShvzNb
Job opportunity: Postdoc position in computational biology. To be co-supervised by myself and @fgaiti. There is still time to apply. #epigenetics #Toronto #genomic #computationalscience #cancerevolution nature.com/naturecareers/…
Our new work assessing the role of NR5A2 and ESRRB in early mouse embryos is out: NR5A2 is essential for morula development. biorxiv.org/content/10.110…
We have a postdoc position available. #TEs, #Trophoblast, #Epigenetics qmul.ac.uk/jobs/vacancies…
Excited to share our recent paper on application of our epigenome editing tools to tackle neurodevelopmental disease. A few points we learned are listed below. Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons science.org/doi/10.1126/sc…
Is there any known, published evidence of physical direct interactions between BAF (SWI/SNF) and NuRD?
📢🎉🎊📢 Here is the final version of our study dissecting in vivo, how regulation of Sox2 by its many distal enhancers interplays with CTCF loops throughout development. Led by @ShreetaChakrab1 nature.com/articles/s4158…
1/ We are excited to share some news about human IRF1, which surprisingly turns out to be the key transcription factor downstream from IFN-gamma and STAT1 in macrophages (sciencedirect.com/science/articl…).
Sox2 expression can be regulated across boundaries generated by CTCF-cohesin loops dlvr.it/Shsm9w
How do cell type specific chromatin features affect binding of STAT transcription factors and gene induction during interferon response? Here comes our @TRR179_2 study on that: doi.org/10.26508/lsa.2…
What drives cell type-specific expression differences in the cortex of Alzheimer’s patients? We used single-nucleus multiomics(ATAC+RNA) to link DEGs to candidate CREs and identify TFs that could contribute to altered regulation.🧵 cell.com/cell-genomics/… #singlecell #Alzheimers
In a patient-driven study, we uncover a unique consequence on 3D Pol2 looping at core regulatory TFs in response to BRD4 degradation! mdpi.com/1424-8247/16/2… Thanks to @kaseeedilla and guest editors @ADurbinLab and @JunQiLab, and the talented folks at @CertisOncology
UBC Life Sciences Institute is hiring 6 (!!!) new faculty members! That's right, 6! 100% hard money, great students, fabulous colleagues (like me!), and living in Vancouver. Apply! Check out the ad here lsi.ubc.ca/2023/01/27/six…
Arginine methylation of CEBPA regulates transdifferentiation by a co-factor transposition mechanism. @idpsig, @AllAboutTFs, @MDC_Berlin, @campusbuch, @epigen_papers, @EpigenChromatin biorxiv.org/content/10.110…
Postdoc position available! - Hanna lab (University of Cambridge) - Topic: epigenetics, placental function, pregnancy - Application deadline: 4th November - Link: jobs.cam.ac.uk/job/37346/ @CTR_Cambridge @Cam_Repro
Interesting new insights into TFs and cell fate: Arginine-methylation controls reprogramming speed of a key transcription factor! biorxiv.org/content/10.110… @generegulation @AllAboutTFs @epigenetichulk @CRGenomica @pioneerfactors @MDC_Berlin
PRIMING EPIGENETIC INHERITANCE!! Ever wonder what determines heritability of a silenced chromatin domain? Histone deacetylation, a conserved heterochromatin feature, is the key to preserving modified histones (H3K9me3) that transmit epigenetic memory nature.com/articles/s4159…
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