Shawn Liu @ShawnLiu_Lab
Assistant Professor @Columbia | CRISPR-Epigenome-Editing-Brain | @DamonRunyon @WhiteheadInst @MIT @Stanford @Purdue alum | Recruiting postdoc and students epibrain.info Manhattan, NY Joined March 2017-
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Shawn Liu retweeted
DNA methylation goes spatial! Introducing Spatial-DMT: a technology that co-profiles DNA methylation and transcriptome in the same tissue section. A fantastic collaboration with @zhouwanding lab. Kudos to Chin Nien Lee @ChinNLee2021 and Hongxiang Fu! biorxiv.org/content/10.110…
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Missing this great place for science!
Missing this great place for science!
Shawn Liu retweeted
Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀
Shawn Liu retweeted
Can we edit the epigenome to restore youth? The surprising answer is yes. Even more surprising is when you reset a subset of DNA methylation sites, other sites are spontaneously reset too. Clearly, there's a lot of exciting biology still to uncover nature.com/articles/s4358…
Shawn Liu retweeted
If the structural similarity between hemoglobin and chlorophyll doesn't fascinate you, then I'm not sure we can be friends.
Shawn Liu retweeted
Just a few months ago, the Baker and Garcia labs released con-concurrent preprints with incredible results. They designed de novo miniproteins that bound specific peptides presented in MHC-I. Now let me show how you can use BindCraft at @AriaxBio to do the same thing.
Shawn Liu retweeted
Jim Carrey had it all: • Golden Globe winner • $20 million per movie • Highest-paid actor by 32 Then he said: 'Jim Carrey doesn't exist.' People said he lost it. But he actually found the truth. 9 profound lessons from Hollywood icon turned spiritual sage: 🧵
Shawn Liu retweeted
In this period of uncertainty, the University will fund research that is subject to stop-work orders or the federal funding freeze, President Schill and Board of Trustees Chair Peter Barris announced today. ▶️ spr.ly/60152zZAv
Shawn Liu retweeted
The most enigmatic structure in cell biology: the Vault. Often missing from science text books due to the mysterious nature of their existence, it has been 40 years since the discovery of these giant, half-empty structures, produced within nearly every cell, of every animals, on…
Shawn Liu retweeted
We have made too little progress on Alzheimer’s, ALS, MS and other diseases of the brain. And often the most innovative research is done by young scientists who have less access to funding. To address this funding gap, @NeriOxman, under the auspices of the @PershingSqFdn…
We have made too little progress on Alzheimer’s, ALS, MS and other diseases of the brain. And often the most innovative research is done by young scientists who have less access to funding. To address this funding gap, @NeriOxman, under the auspices of the @PershingSqFdn…
Shawn Liu retweeted
This is such a cool paper and technology!! Congrats!! Great to see it in print!!
This is such a cool paper and technology!! Congrats!! Great to see it in print!!
Such a honor to receive 2025 MIND Prize @MindPrize. Super grateful for the recognization and support from @PershingSqFdn! Pitching the idea of shortening pathological nucleotide repeats in front of board members is a thrilling experience!
Shawn Liu retweeted
We are proud to announce Bing Ren, PhD, as the new Scientific Director & CEO of the NYGC. Dr. Ren brings his expertise in the fields of genomics & epigenetics to the NYGC & Columbia University, where he will hold a joint appointment. For more on Dr. Ren: bit.ly/3DJXtah
Shawn Liu retweeted
New preprint: The first whole-body map of both DNA methylation and 3D genome organization at single-cell resolution across 16 human tissues, with in-depth analyses of cell type diversity of these epigenome modalities at unprecedented resolutions. (1/5)
Shawn Liu retweeted
Announcing Neo-1: the world’s most advanced atomistic foundation model, unifying structure prediction and all-atom de novo generation for the first time - to decode and design the structure of life 🧵(1/10)
Shawn Liu retweeted
There are days in life that shake you. I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at @Columbia & academic career... 1/🧵
Shawn Liu retweeted
🧬A new imaging technique developed by the Liu Lab uses a novel DNA barcode system to track hundreds of RNA & protein molecules in single cells within thick biological samples, providing a full picture of how these structures are organized inside tissues. janelia.org/news/new-metho…
Shawn Liu retweeted
你无法完全掌控自己的选择。 这位诺贝尔奖得主花了 44 年时间来证明这一点。 他发现了人类大脑中的一个思维漏洞。 一旦你意识到它的存在，你就再也无法忽视。 你甚至会开始怀疑自己做过的每一个决定：🧵
Shawn Liu retweeted
Effortlessly analyze RNA-Seq data with iDEP—now available locally as an R package or Docker container. To get started with Docker, simply run: docker run -d -p 80:3838 gexijin/idep:latest The app and its extensive database will be downloaded automatically. Many researchers…
Shawn Liu retweeted
Safeguarding the future of biomedical science in the United States: Cell cell.com/cell/fulltext/…
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