FunctionalViromics @FViromics
Dr. Michael Letko’s Laboratory of Functional Viromics | we study zoonotic potential of novel viruses | now on Bluesky: @FViromics.bsky.social labs.wsu.edu/lofv/ Pullman, WA Joined January 2020-
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When the COVID-19 pandemic began in 2020, many failed to realize that humanity was still reeling from the AIDS pandemic. We discuss the zoonotic origins of HIV-1 and SARS-CoV-2, the pathogenesis of infection, and available vaccines & therapeutics. 📺 bit.ly/4bbvN9f
Viruses are constantly spilling over between species scientificamerican.com/article/how-ug…
Are you looking for a postdoc where you can apply machine learning tools to predict host-virus interactions from -omics data? We have great PhD students, engaged local colleagues, and a fantastic collaborator network including everyone at @viralemergence! Reach out directly 😊
And don't forget about the amazing satellite sessions including our great speakers on bat viruses including Elke Muhlberger, Eric Laing, @hannahkfrank, @FViromics, @danjbecker and @klphelps with moderation by me and @sci_questions!
And don't forget about the amazing satellite sessions including our great speakers on bat viruses including Elke Muhlberger, Eric Laing, @hannahkfrank, @FViromics, @danjbecker and @klphelps with moderation by me and @sci_questions!
Cool pre-print showing TMPRSS11 members activate ACE2-independent sarbecos biorxiv.org/content/10.110…
That amazing paper you spent years on? That amazing breakthrough you had? Very likely you built this following the work of others (very few exceptions), just as others will build off yours. Science is a continuum. Want to leave a lasting legacy in science? Be generous & be kind.
Check out our latest paper! A deep dive into the recombinant origins of MERS-CoV's Spike protein 🐫🦠 and overall patterns of recombination across the 🦇MERS relatives! Congratulations Jarel for leading this work!! 🎉🎉
Check out our latest paper! A deep dive into the recombinant origins of MERS-CoV's Spike protein 🐫🦠 and overall patterns of recombination across the 🦇MERS relatives! Congratulations Jarel for leading this work!! 🎉🎉
NEW PUBLICATION ‼️ 🦠 We are delighted to share our findings on the influence of recombination on the receptor switching event of MERS-CoV and its close relatives. This paper is now out in @VirologyJ. Please see the threads ⬇️ for some explanation (1/11) virologyj.biomedcentral.com/articles/10.11…
Raising awareness for a Middle East Respiratory Syndrome coronavirus (MERS)-like future pandemic, with ongoing circulation and evolution of merbecoviruses thelancet.com/journals/lance… @TheLancet
The translational potential of studying bat immunity. cell.com/trends/immunol…
@FViromics Great work Michael!
Functional assessment of cell entry and receptor use for merbecoviruses biorxiv.org/cgi/content/sh… #biorxiv_micrbio
Check out the new pre-print from @FViromics probes Merbecoviruses cell entry. Especially the HKU5 viruses use ACE2. 👏👏👏
Check out the new pre-print from @FViromics probes Merbecoviruses cell entry. Especially the HKU5 viruses use ACE2. 👏👏👏
My @WSUvetmed colleague @FViromics probes viral entry
My @WSUvetmed colleague @FViromics probes viral entry
@TSchountz @FViromics This is a very good and a detailed follow up on the report of some bat merbecos using ACE2. What if some bats use more than one receptor (ACE2) to facilitate viral entry? Also, a single author manuscript from a PI = 🤯.
@FViromics Very nice work, Michael. Still reading it but the first thing that popped into my head is that we need to get as many bat ACE2 and DPP4 sequences as we can. Your approach could rapidly generate a threat assessment list of RBD modules in bat coronaviruses.
this is awesome!! HKU5 merbecos use bat ACE2! more evidence that ACE2 usage comes and goes all over the CoV tree. maybe the ancestral receptor of the entire family? 🤔🤔
this is awesome!! HKU5 merbecos use bat ACE2! more evidence that ACE2 usage comes and goes all over the CoV tree. maybe the ancestral receptor of the entire family? 🤔🤔
So an entire clade of MERS-related coronaviruses can use human ACE2 as a receptor, meaning they can infect human cells via the same receptor as SARS-CoV-1 & -2. They have pandemic potential. To be serious about actually preventing pandemics, we can’t prevent virology research.
Arinjay Banerjee @sci_questions
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1K Followers 332 Following Research for bat conservation, head of Department Evolutionary Ecology at @IZWBerlinBryan C Mounce @bryancmounce
7K Followers 2K Following Virology, knitting, bright colors. And a bit of nonsense. Assistant Professor. 🦄🧀🏳️🌈🏋️🌵🧶Robert Gifford @Paleovirologist
3K Followers 2K Following Senior Research Fellow @StellenboschUni Centre for Epidemic Response & innovation (CERI). Evolutionary biologist. Virologist. Creator of GLUE software.Laura Patterson, PhD @Goatlover
474 Followers 2K Following Zoonotic and foodborne pathogen epidemiologist | Currently Epidemiologist for AMHD at Department of Health in Hawai’i. @lpattersgoatSpyros Lytras @SpyrosLytras
3K Followers 1K Following Evolutionary Virologist at the @SystemsVirology lab, University of Tokyo 🇯🇵 Molecular Evolution, Phylogenetics, Viral Genomics (he/him) 💻🔬🏳️🌈Jonathan Heeney @JonathanHeeney
1K Followers 933 Following Professor of Comparative Pathology at Cambridge University. Studies viral diseases transmitted from Animals to Humans, and makes vaccines to stop them."We describe an H5N1 strain of IAV in dairy cattle that resulted in apparent systemic illness, reduced milk production, and abundant virus shedding in milk." Half of cats fed milk from affected cows died. wwwnc.cdc.gov/eid/article/30…
Very cool study describing a huge diversity of corona and nidoviruses hiding in the SRA: 269,000 datasets, 40 nidoviruses from six virus families whose members infect vertebrate hosts. Expand the scale of the known extraordinary evolutionary plasticity 👉journals.plos.org/plospathogens/…
A fun game I play is “How many hosts of this podcast have read the paper they’re discussing?”and today’s number is zero.
Science and education is for all. Congratulations. 👏🏾
At 18, my academic advisor told me that “higher education might not be for you” as I struggled my 1st year at Uni. I was determined to prove him wrong. Yesterday, this first-generation, state-schooled student graduated from Cambridge with a PhD. State school kids, you can do it!
Clearly this was the Roman Institute of Virology and the scholars were trying to model adenovirus capsids from low resolution EMs. bbc.co.uk/news/uk-englan…
If you’re in the market for some H5N1 cattle sequences, look no further. 👇🏻 virological.org/t/note-about-a…
How Ugandan Tobacco Farmers Inadvertently Spread Bat-Borne Viruses | Scientific American scientificamerican.com/article/how-ug…
When the COVID-19 pandemic began in 2020, many failed to realize that humanity was still reeling from the AIDS pandemic. We discuss the zoonotic origins of HIV-1 and SARS-CoV-2, the pathogenesis of infection, and available vaccines & therapeutics. 📺 bit.ly/4bbvN9f
And a back-and-forth between cattle and birds is very bad for a couple of reasons. For one, frequent or repeated switches between a mammalian and avian hosts gives the virus opportunity to adapt to efficiently infecting both.
@rmaviridae NIH did not boost the grant amounts that a PI receives.
There is just no good reason to think there's an epizootic of mammalian adapted H5N1 in birds.
My understanding is that these bird (and cat) viruses within the "bovine" clade were sampled from farms that had bovine H5N1. So, are the birds on these farms giving this virus to the cattle, or are the cattle giving it to the birds? It is cattle to birds very likely.
OK, I think we're close to decisive evidence that US bovine H5N1 had a single origin from birds, and that when related viruses from birds *have* been found, they are jumps from cattle back into birds. Grackles, blackbirds, chickens all show mammalian adaptation like PB2 M631L.
Are you looking for a postdoc where you can apply machine learning tools to predict host-virus interactions from -omics data? We have great PhD students, engaged local colleagues, and a fantastic collaborator network including everyone at @viralemergence! Reach out directly 😊
I am excited to share my new pre-print assessing cell entry for the entire merbecovirus subgenus! Here is the link: tinyurl.com/36nbtjmm. A quick summary of the findings: (1/4)
We know we’ve been quiet here, but we aren’t sleeping on our research! Check out our findings from the first three years of PARIS study: cell.com/immunity/pdfEx… #teamscience #PARISStudy #virusresearch #covid19
And don't forget about the amazing satellite sessions including our great speakers on bat viruses including Elke Muhlberger, Eric Laing, @hannahkfrank, @FViromics, @danjbecker and @klphelps with moderation by me and @sci_questions!
#ASV2024 official conference hotels are completely sold out, but there are still lots of hotel options (some are newly listed on ASV website) and OSU dorms remain available. Looks like the Columbus ASV meeting is gonna be one of the biggest and best ever! asv.org/asv2024/
#ASV2024 official conference hotels are completely sold out, but there are still lots of hotel options (some are newly listed on ASV website) and OSU dorms remain available. Looks like the Columbus ASV meeting is gonna be one of the biggest and best ever! asv.org/asv2024/
It is really hard to see how it is not a scandal that @USDA has not shared what its own FAQs on the situation indicate are *extensive* viral sequence data on H5N1 in cattle in 8 states. aphis.usda.gov/sites/default/… statnews.com/2024/04/18/h5n…
@wanderer_jasnah This is indeed what my average tanglegram looks like 😛 This probably goes beyond βCoVs, we've just got fewer genomes for the other genera. We looked at recombination patterns across taxa and overall patterns look rather similar: academic.oup.com/ve/article/8/2…