Tom Peacock @PeacockFlu
Virologist. Viruses, Influenza, Coronaviruses and SARS-CoV-2. Typos are intenitonal. Fellow at @Pirbright_Inst and @ImperialInfect Joined December 2011-
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It's starting to look like pasteurization inactivates #H5N1 #birdflu viruses in milk. But people who drink raw milk are playing with fire right now. statnews.com/2024/04/29/bir…
📣 Attention early-career researchers! The Pirbright Strategic Career Development Award (CDA) provides experience and independence to support career development while delivering strategically important science. Find out more and apply ➡️ ow.ly/9EWI50Rp55L
Great opportunity for folks interested in starting their own group (or moving an existing group) working in the areas of livestock viruses or immunology, zoonotic diseases, vaccinology, or insect vector biology! Come work with us!
Great opportunity for folks interested in starting their own group (or moving an existing group) working in the areas of livestock viruses or immunology, zoonotic diseases, vaccinology, or insect vector biology! Come work with us!
My colleagues and I have just posted a "Note about availability of #H5N1 2.3.4.4b consensus sequences from cattle and other species" @virological_org. Consensus genomes and metadata. virological.org/t/note-about-a…
We need to talk about that human case of H5N1 in Texas... Here is a bootstrapped (NJ) tree showing how the closest realtive of H5N1 sampled in cattle is a virus the infected an male individual who reportedly worked on a farm with cattle (dairy, I believe).
Important update on metadata of H5N1 in cattle (and back to birds): Thanks to the extraordinary detective skills of @flodebarre, we are pleased to be able to share this table containing locations and dates for several H5N1 cases in cattle and birds: github.com/andersen-lab/a…
Due to enormous and collaborative effort from the @nextstrain team, @hamesjadfield @trvrb and of course @USDA , we now have the USDA cattle sequences on Nextstrain: nextstrain.org/avian-flu/h5n1… visualized with new, 2-year builds.
The discovery of #H5N1 #birdflu in a significant portion of commercially purchased milk suggests the outbreak in cows is much larger than we know, scientists who've been doing this work tell @MeganMolteni. statnews.com/2024/04/25/h5n…
So, *preliminary* molecular clock analyses indicate that the time of the most recent common ancestor (TMRCA) of the US cattle flu clade was late December. TMRCA of that clade and the closest relatives in birds, mid-December. If single intro, likely between those rough dates.
Interesting tidbits from a press conf today on #H5N1 #birdflu by US agencies —NIAID-funded researchers found commercial milk that was PCR-pos for H5, but could not grow live virus from it. (Good) —USDA & CDC admitted some farmers won't let them test. statnews.com/2024/04/24/h5n…
JOBS: Come and join us at The Pirbright Institute and lead innovative research in virology or immunology focused on high consequence livestock viral diseases. Apply now to become a Group Leader or Fellow ➡️ ow.ly/upjV50Rm4VK
We're hiring a full-time, computational biologist/software engineer to contribute to our efforts on @nextstrain avian-flu and viral evolution! See details here: wd1.myworkdaysite.com/recruiting/upe…
Here's a visual of the US H5N1 "Cattle clade", HA plus two internal genes. Strongly suggests to me there was single origin, at least for these sequences. Possibly in late 2023/early 2024.
Here is a link to 239 consensus genome sequences, assembled by @xrayfoo, from sequencing reads of 2.3.4.4b H5N1 influenza A virus from cattle and other species. github.com/andersen-lab/a…
A short distraction from MooFlu (© @tompkins_lab) to BatFlu: 'The bat-borne influenza A virus H9N2 exhibits a set of unexpected pre-pandemic features' from @MartinSchwemmle and company assets.researchsquare.com/files/rs-29375…
Jeff Gilchrist @jeffgilchrist
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@PeacockFlu @PSchneider_IAS @B_Dogs4 @freakinbox Thank you @PeacockFlu
@freakinbox @B_Dogs4 It is interesting to see the H5N1 studies in non-human primates. This one found the dose and method of administration of the virus greatly influenced pathogenicity and mortality. @PeacockFlu ncbi.nlm.nih.gov/pmc/articles/P…
„Although the US Food and Drug Administration has indicated the commercial milk supply remains safe, the detection of influenza virus in unpasteurized bovine milk is a concern because of potential cross-species transmission.“ Interesting read on #h5n1 in cows and cats:…
Bird flu virus has been spreading in US cows for months, RNA reveals nature.com/articles/d4158…
New Houldcroft lab preprint! doi.org/10.1101/2024.0… What does the landscape of T cell immunity to adenoviruses look like in healthy English adults (and why should we care)?
Nothing quite like posting a preprint to trigger an avalanche of predatory journal emails :/
@PeacockFlu @B_Dogs4 @freakinbox Almost like it depends on what mucus membrane is exposed.
@PeacockFlu @B_Dogs4 @freakinbox It seems some of these species with high mortality have lots of virus in brain tissue, whereas in cattle the virus seems to have affinity for mammary tissue. Do we know what the viral tropism is in humans and does that very by different clades of high path H5N1?
It's starting to look like pasteurization inactivates #H5N1 #birdflu viruses in milk. But people who drink raw milk are playing with fire right now. statnews.com/2024/04/29/bir…
There's no justification for continued use of molnupiravir. Australia changed official guidance, yet the clinical impact seems limited. Recent sequences indicate Japan, S Korea, Australia, & USA are the major MOV users. Most recent seq, uploaded today from Korea, pictured below.
I've started extracting the stats on Molnupiravir and Paxlovid prescribing for Residential Aged Care facilities in Australia. It reveals that Paxlovid is only being given to around 10-15% of Resident cases. Most cases are receiving Molnupiravir. 🧵
Experts say the the danger associated with raw milk consumption may have gone to a whole new level as bird flu spreads among cows. trib.al/D9Glj8P
We're hiring new principal investigators (fellows and group leaders) who want to work on livestock and zoonotic viruses at The Pirbright Institute (@Pirbright_Inst). Come join us! We have core funding, a collaborative approach to science, and access to some phenomenal facilities
JOBS: Come and join us at The Pirbright Institute and lead innovative research in virology or immunology focused on high consequence livestock viral diseases. Apply now to become a Group Leader or Fellow ➡️ ow.ly/upjV50Rm4VK
Out of 33 dairy farms in 8 U.S. states (+1 dairy farm in Colorado), 23 people have been tested for highly pathogenic avian influenza H5N1 by states. Less than 1 person per farm. This seems a clear answer to the question: “Are we testing enough for H5N1?” medpagetoday.com/special-report…
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📣 Attention early-career researchers! The Pirbright Strategic Career Development Award (CDA) provides experience and independence to support career development while delivering strategically important science. Find out more and apply ➡️ ow.ly/9EWI50Rp55L
📣 Attention early-career researchers! The Pirbright Strategic Career Development Award (CDA) provides experience and independence to support career development while delivering strategically important science. Find out more and apply ➡️ ow.ly/9EWI50Rp55L
"FDA has received additional results from an initial limited set of geographically targeted samples...prelim results of egg inoculation tests on..qPCR-positive retail milk samples show that pasteurization is effective in inactivating HPAI." flutrackers.com/forum/forum/na… h/t Lance #H5N1
@PeacockFlu @thijskuiken All good, good news so far nevertheless!
@thijskuiken I thought the current outbreak was only picking up internal gene mutations 💀 are these HA mutations something H5N1 already has or is it genuinely starting to switch receptors? @PeacockFlu
A note: We are copying from X genetics posts about the US #H5N1 situation and posting on our genetics thread. The virologists that we h/t are not directly posting on our site but we want to acknowledge them as some of the authors. Thank you for everyone's work. :)