Schwemmle Lab @MartinSchwemmle
Studying viruses and viral zoonosis @Uniklinik_Fr Freiburg, Germany Joined January 2020-
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Happy to share our latest piece on #BatFlu. In collaboration with Martin Beer's group @Loeffler_News, Thorsten Wolff @rki_de, @florian_krammer, and @MartinSchwemmle we show that bat H9N2 fulfils key criteria for pre-pandemic IAVs. rdcu.be/dFJgi
Students & postdocs, sign up for the @GesVirologie workshop on zoonotic viruses and One Health. Great keynotes from @MarionKoopmans, Neil Vora @conservationdoc, Renke Lühken @LuehkenEcology, Sandra Junglen @ChariteBerlin, and Rainer Ulrich from FLI @Loeffler_News.
Step by step, the mystery of influenza A virus genome packaging is being unraveled. Great work from our group on how viral NP and RNA coordinate genome packaging, now online @JVirology.
Step by step, the mystery of influenza A virus genome packaging is being unraveled. Great work from our group on how viral NP and RNA coordinate genome packaging, now online @JVirology.
@Uniklinik_Fr & @Loeffler_News advocate a watch and prepare approach to #avianinfluenza. After so many years, many hurdles still stand in the way of adaptation to humans. And MxA is an important hurdle that has yet to be overcome. 👇 rdcu.be/dkJUn
Antiviral restriction factors prevent human infections with zoonotic influenza A viruses, yet IAVs evolve to escape them. Dr. Laura Graf (not on twitter), @MartinSchwemmle and I wrote a @PLOSPathogens Pearl to sum up some recent findings! Check it out: dx.plos.org/10.1371/journa…
Bat #influenza A viruses use MHC-II for cell entry; @kikmelody &co show that conserved amino acids within MHC-II are key for infection & explain the ability of these #viruses to target MHC-II from a broad range of vertebrates (incl humans) #PLOSBiology plos.io/3XDMqot
Did you know that bat flu uses highly conserved residues in MHC-II molecules for cell entry? Check our recent paper published in @PLOSBiology. Many thanks to all partners involved. doi.org/10.1371/journa…
If you are interested in the antiviral mechanisms against zoonotic influenza A viruses, then join our team. We have two 4-year #PhDpositions available at the Institute of Virology in Freiburg.
Fantastic work by @PetricPhilipp and @Loeffler_News was selcted by the @VirusesMDPI editorial team. We show that avian H7N9 viruses can partially overcome MxA-restriction through polymerase mutations. mdpi.com/1999-4915/14/1…
🔝Editor's choice article: H7N9 #influenza A #virus is highly sensitive to restriction by MxA. Experimental adaptation of H7N9 in MxAtg/-Rag2-/- mice led to the selection of PB2-E627K, a #mutation enabling partial escape from MxA. More details here: mdpi.com/1999-4915/14/1…
Happy to share our latest article published @JournalSpectrum. We developed a novel attenuated chimeric bat influenza A virus live-vaccine prototype. Thanks to our collaboration partners @Loeffler_News. @MartinSchwemmle @RanWei17002958 Check our story: journals.asm.org/doi/10.1128/sp…
Finally out. Circulating multimeric immune complexes contribute to immunopathology in COVID-19. Great work by our medical student @jak_ank and the other co-authors involved. Fantastic job. nature.com/articles/s4146…
Our study showing that severe COVID-19 in the aged organism is caused by an age-dependently impaired type I and type II interferon response, is now available in @JExpMed! Congrats and thanks to all collaborators, especially to first author Julius Beer! @MartinSchwemmle
Our study showing that severe COVID-19 in the aged organism is caused by an age-dependently impaired type I and type II interferon response, is now available in @JExpMed! Congrats and thanks to all collaborators, especially to first author Julius Beer! @MartinSchwemmle
Super happy to share our latest preprint addressing the pathomechanisms of the age-dependent disease severity of COVID-19! It was a great team effort over the last 1.5 years! biorxiv.org/content/10.110…
Very much looking forward to meeting Adolfo Garcia-Sastre from @IcahnMountSinai on Monday. He will talk about SARS-CoV-2 virus-host interactions. Seminar is open to anyone interested.
Looking very much forward to meet @wrobel_antoni from the @TheCrick. His talk about "Evolution of SARS-CoV-2 spike" is open to anyone interested.
Happy to share our new piece published in @VirusesMDPI together with Tony Schountz and @MartinSchwemmle. Read about Jamaican fruit bats and their viriome. mdpi.com/1999-4915/14/2…
Immunocompromised patients could be a source for the emergence of potentially harmful #SARSCoV2 #variants. Paper co-authored by EVBC member @MartinSchwemmle doi.org/10.1038/s41467…
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774 Followers 408 Following molecular virologist working with his group on glycoscience! #chemicalbioUU
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UZH Medical Virology @UZH_Virology
2K Followers 57 Following Research, diagnostics & teaching in human viral disease @UZH_en. #HIV #influenza #SARSCoV2 #vaccines #immunity. Grps @ATrkola Stertz @BenHalePhD @mihuberHappy to share our latest piece on #BatFlu. In collaboration with Martin Beer's group @Loeffler_News, Thorsten Wolff @rki_de, @florian_krammer, and @MartinSchwemmle we show that bat H9N2 fulfils key criteria for pre-pandemic IAVs. rdcu.be/dFJgi
Students & postdocs, sign up for the @GesVirologie workshop on zoonotic viruses and One Health. Great keynotes from @MarionKoopmans, Neil Vora @conservationdoc, Renke Lühken @LuehkenEcology, Sandra Junglen @ChariteBerlin, and Rainer Ulrich from FLI @Loeffler_News.
Happy to share our latest piece on #IAV genome packaging. We provide evidence that genome packaging is mediated by the charge of single NP amino acids in combination with RNA packaging signals. Check out the study: doi.org/10.1128/jvi.01…
Happy to share our latest article published @JournalSpectrum. We developed a novel attenuated chimeric bat influenza A virus live-vaccine prototype. Thanks to our collaboration partners @Loeffler_News. @MartinSchwemmle @RanWei17002958 Check our story: journals.asm.org/doi/10.1128/sp…
Excited! "3rd International Symposium on Infectious Diseases of Bats" in Fort Collins. -->batid.org Registration closes soon. Who else is attending?
Fantastic work of the @teximmed2 lab (Maike Hofmann, Robert Thimme and Christoph Neumann-Haefelin) and the @MartinSchwemmle lab. Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine. nature.com/articles/s4158…
Thanks again to everyone involved in this exciting collaborative project! @MartinSchwemmle @Rizzi_Marta @KCiminski @ValerieOben #VaccinesWork
Fantastic work of the @teximmed2 lab (Maike Hofmann, Robert Thimme and Christoph Neumann-Haefelin) and the @MartinSchwemmle lab. Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine. nature.com/articles/s4158…
Excited to share: Response of T cells following bnt162b2 prime vaccination. Great collaborative work of the @teximmed2 and the @MartinSchwemmle lab published @Nature. nature.com/articles/s4158…
Spread of #SARSCoV2 infection during #lockdown in southwest Germany particularly low in #children aged 1-10. It is unlikely that children have boosted the pandemic. Paper co-authored by EVBC member @MartinSchwemmle doi.org/10.1001/jamape…
Work led by co-first authors Vy Tran and @mitchnviruses. Fruitful collaborations with a number of groups, especially Van Thamamongood in @MartinSchwemmle lab sharing data from their independent CRISPR screen. So much better to collaborate than to rush out competing stories. 2/n
@MartinSchwemmle @Loeffler_News Ha! I did not know that the Schwemmle lab is on twitter!
Came back from Freiburg visting @MartinSchwemmle like always couldnt help it to get some quality meats! Thanks again for the invite Martin!
Congrats @MelleHolwerda @PhilipVkovski Manon and @DijkmanRonald !
Great start of the week! In this paper, we describe the use of the 'Pandemic Response Box' compound library against #SARSCoV2 and found 5 antivirals that could inhibit the virus at least as potent as Remdesivir, with different suggested mode of actions! tinyurl.com/SARS2PRB
Now out @Nature! Cloning a coronavirus is one week. Thanks @Thao_TTN @FLabroussaa @nebert59990508, the twitterless JJ, @DijkmanRonald @PhilipVkovski @MelleHolwerda @stalder3012bern... Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform disq.us/t/3oewcos
The discovery of #IAV in #bats did severely challenge our previous conception of IAV host range and #phylogeny, as they reveal the true power of IAV adaptability; Q&A co-authored by EVBC members M. Beer and @MartinSchwemmle dx.doi.org/10.1371/journa…
@MartinSchwemmle @HarmitMalik Congrats Martin and team!! This bat stuff is the gift that keeps giving..🦇
@MartinSchwemmle Wow, Martin! Das ist echt richtig cool und hoch verdient! Glückwunsch!!
@MartinSchwemmle Oh wow. You are the champion. Looking forward to more cool studies of yours et al. 💪🏼👏👍🏽
@MartinSchwemmle Hey congrats! Sure your bat project will fly.
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