Longevity Explorer @LongevityExplor
Lifespan&Healthspan&🥩&Muscle&Telomeres&🏋♂️Sun& Fasting &Grounding centenars bacteria:Bacteroides/Akkermansia/Escherichia/Hungatella/Phascolarctobacterium Amsterdam, The Netherlands Joined November 2019-
Tweets21K
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Followers2K
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Following7K
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Likes20K
Longevity Explorer retweeted
Cancer is a metabolic / mitochondrial disease in nature. I've written here about all of the angles one would take to optimize mitochondrial function: x.com/Outdoctrinatio…
Cancer is a metabolic / mitochondrial disease in nature. I've written here about all of the angles one would take to optimize mitochondrial function: x.com/Outdoctrinatio…
Longevity Explorer retweeted
Another key component to solving cancer is proper immune functioning, since it is the immune system that actually clears out tumors. While chemo (cisplatin) worsened anti-tumor immunity, the healthy mitochondria increased: ◉ CD4+ area - a marker of T helper cells ◉ CD8+ area…
Longevity Explorer retweeted
With healthy mitochondria, cancer cells are able to kill themselves properly. They could produce more ROS and were able to induce programmed cell death (TUNEL), processes that are impaired in cancer and lead to the cells' accumulation. (7/8)
Longevity Explorer retweeted
Reversing the mitochondrial dysfunction in cancer cells also reversed the other hallmarks of cancer. For instance, healthy mitochondria reduced HIF1α, a key mediator of cancer invasion. It also reduced the "stemness" or the ability of cancer cells to turn into cancer stem…
Longevity Explorer retweeted
Healthy mitochondria also shrank tumor growth in animals. Greatly enhanced the effectiveness of the chemo. (5/8)
Longevity Explorer retweeted
When lung cancer cells received the healthy mitochondria, they became more sensitized to chemotherapy. A higher concentration of healthy mitochondria cut the amount of chemo (cisplatin) needed to kill the cancer cells by around half. (4/8)
Longevity Explorer retweeted
When mitochondria are not working properly, it is a breeding ground for cancer. ◈ More reactive oxygen species produced ◈ Greater acidification ◈ More oncometabolites ◈ Aberrant epigenetic signaling ◈ Worsened immune function ◈ Impaired cell death ◈ Improper cycle…
Longevity Explorer retweeted
The metabolic origins of cancer have been known for about a century. Nobel prize winner Otto Warburg noted that cancer cells had inefficient metabolism - they turned glucose into lactic acid preferentially, instead of into CO2. Why this helps cancer grow has been revealed more…
Longevity Explorer retweeted
Cancer starts in the mitochondria, & fixing them might treat it - a groundbreaking study shows it more clearly than ever. (🧵1/8)
Cancer starts in the mitochondria, & fixing them might treat it - a groundbreaking study shows it more clearly than ever. (🧵1/8) https://t.co/E3Exh0j7yr
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