MacMillan Group @MacMillan_Lab
Shining light on organic chemistry chemlabs.princeton.edu/macmillan/ Princeton, NJ Joined June 2015-
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Old tissue, new tricks?? We introduce μMap-FFPE—a high-resolution protein photoproximity labeling platform for archived FFPE tissue. Check out this paper for your spatial proteomics needs and to learn more about CD20 in clinical tissue samples. 📃: doi.org/10.1021/jacs.5…
With thanks to these esteemed early-career researchers Steve, Sijbren, Alex, Kristina, and Erik who presented at yesterday’s Princeton Catalysis Initiative Symposium opener. Well done, all.
‘Tis the season! Here, Noah Bissonnette of the @MacMillan_Lab during his dissertation defense, and being introduced by adviser David MacMillan. Best of luck to all graduate students defending this spring! You are our future.
Alcohols + aryl acids = C(sp3)–C(sp2) bonds! In collaboration with @LongLabCal & Merck Boston, we combine NHC-deoxygenation & Ni-catalyzed decarbonylation to link overlooked building blocks. Congrats Eva, Johnny, Edna, Stephanie, Kurtis, Cesar & Ryan! pubs.acs.org/doi/10.1021/ja…
Thrilled to announce that Brandon Bloomer of the @MacMillan_Lab has been named a 2025 @BeckmanFnd Postdoctoral Fellow in the chemical sciences, one of just 14 across the country. Congratulations, Brandon! Announcement here: bit.ly/3S1KAvr
Check out our newest work in Chem to achieve 3-functionalization of BCPs to access diverse aryl bioisosteres. Congrats Kat! Give it a read here: cell.com/chem/abstract/…
Want to selectively couple two radicals?... You're in luck! Check out our newest work in Nature where we use dynamic orbital selection to unlock alkylation of native aryl C–H bonds. Congrats to @GrosskopfJo, Charlene, Robert, and Alex! Read more at: nature.com/articles/s4158…
Spring into some great seminars from @POCC_Chem ! Next week's installment is @PrincetonChem very own @dmac68 for our Allan Day award lecture. Prof, MacMillan will be discussing research from @MacMillan_Lab including organocatalysis, photoredox catalysis, and microenvironment…
Check out our latest work in JACS, where we sort nitrogen-centered radicals and alkyl radicals across alkenes in a regioselective aminoalkylation reaction. Congrats to Will, Johnny, and our collaborator Jesús from Janssen Spain! pubs.acs.org/doi/10.1021/ja…
Parallel Proteomic & Transcriptomic Microenvironment Mapping (μMap) of Nuclear Condensates in Living Cells Journal of the American Chemical Society @dmac68 @MacMillan_Lab @PrincetonChem #Proteomic #Transcriptomic #Mapping #Nuclear #Condensates #LivingCells pubs.acs.org/doi/10.1021/ja…
Check out this latest work in JACS from Steve, Roderick, Niels, Brandon, Philip, and Iakovos! 🎄 pubs.acs.org/doi/10.1021/ja…
Check out this latest work in JACS from Steve, Roderick, Niels, Brandon, Philip, and Iakovos! 🎄 pubs.acs.org/doi/10.1021/ja…
Nothing like a little holiday cheer in the lab! Our chemistry department got a surprise visit from therapy dogs today—bringing smiles, tail wags, and a much-needed break from the bench. 🐾✨ #LabLife #HolidayCheer #TherapyDogs #ScienceAndSmiles
Check out our latest work in JACS— Access to a nucleophilic Fe(I) complex allows for activation of 1° electrophiles via an SN2-type mechanism. Subsequent SH2 bond formation enables all-carbon quaternary centers. Congrats Andria, Felix, Wei, and Marissa! pubs.acs.org/doi/full/10.10…
Our latest chemical biology paper is out now in JACS! We developed a platform to profile the phagocytic surface proteome in a temporally resolved manner. Congrats to Sean, Jacob and James! @HuthSean @JacobGeri1 @JamesO760
Our latest chemical biology paper is out now in JACS! We developed a platform to profile the phagocytic surface proteome in a temporally resolved manner. Congrats to Sean, Jacob and James! @HuthSean @JacobGeri1 @JamesO760
It was a pleasure for the @MacMillan_Lab to host high school organic chemistry students from the @trevordayschool in NYC today. Thanks to Andria Pace @princetonwic, Will Lyon, and @dmac68 for giving them an idea of what we do here at Frick Lab!
Check out our latest article in Nature Chemical Biology where an intracellular micromap proximity labeling platform is established to investigate stress granule disassembly mechanisms. Congrats to Roderick, Steve and Sean! nature.com/articles/s4158…
Farewell, Vittorio and Ryan! It's been a pleasure having you both in the lab, sharing your knowledge and passion for chemistry. Wishing you all the best in your next adventure. You'll be missed! #SafeTravels
Congratulations to our German postdoc Johannes Grosskopf (@GrosskopfJo) who has been awarded the 2024 Albert-Weller award by the German Chemical Society @PhotochemGDCh for his outstanding contributions to photochemistry as a young academic. Well done, Johannes!
For any cyclopropane fans – ICYMI, see our latest report in @Nature. Using one-electron logic, iron carbenes can be made from simple reagents like lactic acid, trifluoroethanol or alanine. Congrats to Ben, Nate and our awesome collaborators at Janssen! nature.com/articles/s4158…
Congratulations to the @MacMillan_Lab for their latest, just out in @Nature: “Unlocking carbene reactivity by metallaphotoredox a-elimination.” Great work by Ben, Nathan, Dave and colleagues at Janssen: bit.ly/4ebrtsH
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222 Followers 104 Following 15th European Conference on Organic Free Radicals The University of Manchester, 1-4 September 2024
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135 Followers 154 Following Leopoldina Postdoc-Fellow in the @MacMillan_Lab | PhD with @bach_lab | Amazed by💡, ⚡️ and Catalysis | Dog and Coffee Lover | Swiftie by Heart | 🏳️🌈
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