Manuel Friese @ManuelFriese
Professor of Neurology | Director Institute of Neuroimmunology and Multiple Sclerosis, UKE inims.de Joined September 2020-
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Manuel Friese retweeted
RVCL is a rare genetic disease that can cause blindness, dementia, and organ failure. McGlasson et al. show that RVCL arises when mutations cause the enzyme TREX1 to mislocalize to the nucleus of endothelial cells, where it causes DNA damage. tinyurl.com/jdh9wpre
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Manuel Friese retweeted
Our study on the protective role of CLEC16A in astrocytes in MS is out today in @NatureNeuro! Congrats to Atsushi and all collaborators! nature.com/articles/s4159…
We are hiring (2 positions) one Postdoctoral fellow and one Clinician-Scientist (all genders) in neuroimmunological research | Universitätsklinikum Hamburg-Eppendorf uke.jobs/index.php?ac=j… uke.jobs/index.php?ac=j…
Manuel Friese retweeted
🧠 Once smoldering inflammation begins, neurons may undergo irreversible changes and eventually degenerate, explains Prof. @ManuelFriese from @UKEHamburg. Targeting this process is the next big challenge in #MS research. Read more here: bit.ly/3PMkyeQ
Manuel Friese retweeted
@ManuelFriese @Brain1878 great work shedding light on the applications of CAR T cells !
@ManuelFriese @Brain1878 great work shedding light on the applications of CAR T cells !
Check out our results from an academic drug development program targeting TRPM4 to protect neurons from neurodegeneration. Many years of intense collaboration between @inims_hamburg @UKEHamburg @Fraunhofer @KU_Leuven @Evotec cell.com/iscience/fullt…
Manuel Friese retweeted
Our perspective in @ScienceMagazine on #Ferroptosis—#disease perils and #therapeutic promise science.org/doi/10.1126/sc… written for a general audience -- not too technical. Congrats to authors @ashleybrown015 and Tal Hirschhorn! @Columbia
Manuel Friese retweeted
»Toleranz wird zum Verbrechen, wenn sie dem Bösen gilt.« Am heutigen Tag vor 100 Jahren erschien „Der Zauberberg“ von Thomas Mann.
Manuel Friese retweeted
tidyplots is now on CRAN 🚀 tidyplots.org #tidyverse #rstats #Rpackage #DataAnalytics #DataScience #ggplot2
Manuel Friese retweeted
🚀 Thrilled to announce the launch of Phase 2 funding for #SPP2306! After an incredibly productive first phase, we’re ready to push the boundaries of 🔬 science. Huge thanks to everyone for the inspiring discussions and groundbreaking ideas—let’s keep the momentum going! 🔥🔥
Check out our new findings from @inims_hamburg - Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis | Nature Communications nature.com/articles/s4146…
Manuel Friese retweeted
I've recently discovered a really useful R package by Jan Broder Engler called tidyheatmaps. It's designed to make creating heatmaps from tidy data easy, especially for publication-quality visuals. The package uses pheatmap for detailed heatmaps with less coding. If you work…
Manuel Friese retweeted
New paper out @Nature - why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? sex chromosomes or hormones? Here we studied adaptation of human immune systems to gender-affirming…
Manuel Friese retweeted
How das chronic hyperexcitability contribute to #neurodegeneration in #MS? Check out our journey published now in @jclinicalinvest with the incredibly talented @bal_lukas 🎓 from the @inims_hamburg @ManuelFriese 🎉🔥 jci.org/articles/view/…
Out now: How does inflammation impact hyperexcitability and metabolism in neurons during #multiplesclerosis. Again great collaboration @merkler_lab @glatzel_markus and others! Spearheaded by the MDs @woo_marcel @bal_lukas jci.org/articles/view/…
Manuel Friese retweeted
Great paper identifying a mechanism of inflammation-induced neurodegeneration in MS! Check out the preview written by @hong_lee89 doi.org/10.1016/j.molc…
Great paper identifying a mechanism of inflammation-induced neurodegeneration in MS! Check out the preview written by @hong_lee89 doi.org/10.1016/j.molc…
Manuel Friese retweeted
Forschende des #UKEHamburg haben in einer Studie einen Mechanismus für das Absterben entzündeter Nervenzellen bei #MS entdeckt und das hierfür entscheidende Schlüsselprotein identifiziert. Damit könnten sich neue Ansatzpunkte für die MS-Therapie ergeben: uke.de/allgemein/pres…
Manuel Friese retweeted
#WeekendRead! #EveryCellIsAnImmuneCell! @woo_marcel @Mayer_chr @ManuelFriese &co show @CellCellPress that #InterferonGamma induces STING in #neurons that upon glutamate excitotoxicity detaches from STIM1 to drive ferroptosis aggravating #MultipleSclerosis! cell.com/cell/fulltext/…
Manuel Friese retweeted
Now online! STING orchestrates the neuronal inflammatory stress response in multiple sclerosis dlvr.it/T8HhbT
Proud to present our findings in @CellCellPress about neuronal STING as integrator of inflammatory and glutamate signals in #multiplesclerosis. Great work by @woo_marcel , @Mayer_chr , @inims_hamburg collaborators @merkler_lab @Conrad_Lab @glatzel_markus cell.com/cell/fulltext/…
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