Paul Datlinger @PaulDatlinger
Scientist. Inventor of CROP-seq & scifi-RNA-seq. Associate Director at the Arc Institute | Virtual Cell Initiative Joined March 2017-
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Paul Datlinger retweeted
Today, Arc announced it is joining forces with @NVIDIAHealth to develop powerful computational tools that will help researchers everywhere explore and understand living systems in ways previously impossible. arcinstitute.org/news/news/arc-…
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Paul Datlinger retweeted
Excited to partner with @nvidia and @nvidiaHealth to scale the potential of AI models to design, predict, and understand biology. Our goal is to discover emergent properties of life, similar to those found in language, videos, and robotics arcinstitute.org/news/news/arc-…
Interested to screen T cells for Arc’s Virtual Cell Initiative and explore AI virtual cells in cancer immunotherapy? I’m looking for a talented Scientist to join my team at the @arcinstitute in Palo Alto, California. Apply here! grnh.se/c565d05f4us
Paul Datlinger retweeted
Enjoyed writing this perspective on an AI-powered virtual cell with amazing collaborators But it’s been even more fun actually building it! 🔧 Check out open positions @arcinstitute or find us @NeurIPSConf
Enjoyed writing this perspective on an AI-powered virtual cell with amazing collaborators But it’s been even more fun actually building it! 🔧 Check out open positions @arcinstitute or find us @NeurIPSConf
Paul Datlinger retweeted
In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! biorxiv.org/content/10.110…
Paul Datlinger retweeted
🧬Evo, the first foundation model trained at scale on DNA, is a Rosetta Stone for biology. DNA, RNA, and proteins are the fundamental molecules of life—and cracking the code of their complex language is an ongoing grand challenge. 🔬Today in @ScienceMagazine, the labs of Arc…
Paul Datlinger retweeted
"If you asked an AI to generate a brand-new drug discovery biotech with a team of some of the biggest names in the biz for you, it couldn’t dream up one like Xaira Therapeutics." fiercebiotech.com/biotech/new-ai…
Press release: businesswire.com/news/home/2024…
Integrated scATAC/scRNA-seq analysis of TILs, elegantly validated by enhancer editing. Congratulations to Christian Schmidl and team on this beautiful story and the first paper from the new lab!
Integrated scATAC/scRNA-seq analysis of TILs, elegantly validated by enhancer editing. Congratulations to Christian Schmidl and team on this beautiful story and the first paper from the new lab!
Paul Datlinger retweeted
scifi-RNA-seq improves the throughput of droplet-based scRNA-seq up to sequencing millions of cells in a single experiment. @BockLab @CeMM_News nature.com/articles/s4159…
I prepared this Tweetorial as a quick introduction to the scifi-RNA-seq technology. Please check it out if you are interested in ultra-high-throughput and highly multiplexed scRNA-seq.
I prepared this Tweetorial as a quick introduction to the scifi-RNA-seq technology. Please check it out if you are interested in ultra-high-throughput and highly multiplexed scRNA-seq.
Compared to our preprint the article includes extensive benchmarking to @10xGenomics and plate-based combinatorial indexing. We included a CRISPR screen with scRNA-seq readout of T cell activation. Round1 barcodes are ideal for large perturbation screens with single-cell readout.
Cell atlas projects and single-cell perturbation screens require cost-effective profiling for millions of cells or thousands of experimental conditions. Our new method scifi-RNA-seq supports projects of this scale. Article published today @naturemethods: nature.com/articles/s4159…
Paul Datlinger retweeted
The landscape of human cells! From Guoji Guo's lab- single-cell RNA-seq of 500,000 cells across 60 human tissues. Also includes biological replicates, detailed annotation, and open code/data: nature.com/articles/s4158…
Paul Datlinger retweeted
With Fei Chen's lab, we increase Slide-seq mRNA detection 10-fold, transforming what we can discover in these data. It's our last preprint as we prepare to shut down the lab for #COVID19. Time to catch up on #bioRxiv reading! Stay healthy. biorxiv.org/content/10.110…
Paul Datlinger retweeted
KB: So today we are pleased to introduce the Chromium Single Cell ATAC + Gene Expression solution. 2 modalities in one simple workflow, both at high sensitivity. #AGBT20
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