The complement system detects & eliminates pathogens; however, when overactivated, it can become harmful to the host. Rafael Bayarri-Olmos et al. summarize the latest understanding of the role of complement in #LongCOVID pathogenesis (open access)👇🏼 (1/)
insight.jci.org/articles/view/…
Montreal researchers studied 249 ME patients and found that elevated SMPDL3B in blood tracks with symptom severity.
Two diabetes drugs, vildagliptin and saxagliptin, reversed this effect in immune cells, hinting at a new treatment path.
…nslational-medicine.biomedcentral.com/articles/10.11…
Jakarta study of 47 COVID-19 patients found that obese individuals who developed higher insulin resistance a year later had fewer functional virus-fighting CD4 T cells, linking weakened immunity to lasting metabolic problems.
nature.com/articles/s4159…
We've announced our new study, called COVID-4.019-Long, which further expands our clinical research efforts to assess ANKTIVA’s potential beyond cancer or cancer-related diseases. Learn more about the study and its potential impact: ir.immunitybio.com/news-releases/…
For those who unfortunately have Long Covid either from the infection or vaccine we now have opened a trial with Anktiva Bioshield to explore if the NK cells we activate can clear the cells that may persist with virus . @ cssifm.org
For those who unfortunately have Long Covid either from the infection or vaccine we now have opened a trial with Anktiva Bioshield to explore if the NK cells we activate can clear the cells that may persist with virus . @ cssifm.org
1/ Millions are living with long-term illness after infection, often without answers.
Today, we’re launching the USA's first clinical manual for treating Infection-Associated Chronic Illnesses (IACIs).
#LongCOVID#MECFS#Lyme
🔗 Read the announcement: mountsinai.org/about/newsroom…
🔬Interesting new study: Researchers exposed lab-grown human muscle tissues to blood serum from people with ME/CFS and Long COVID.
After 48 muscles:
- Produced less force
- Fatigued faster
- Lost their ability to hold peak strength
Let’s breakdown the full paper 🧵
Most rare diseases aren’t “uncurable.”
They’re just unfunded.
Pharma ignores them because there’s no billion-dollar market to chase.
Governments move at the speed of paperwork.
The cure will come from patients, scientists, and AI agents pooling resources onchain, funding…
Our initial DNA results! DecodeME have discovered that people with an ME/CFS diagnosis have significant genetic differences compared to the general population. Summary of our results: shorturl.at/pgsjk Check out our full preprint paper: shorturl.at/VwN3s
ME, or Myalgic encephalomyelitis, is linked to your genetics, an early study by Decode ME has suggested.
They’ve found eight areas of genetic code in people with ME are ‘significantly different’ to the DNA of people without the disease.
The results still need to be reviewed,…
UK-based DecodeME recruited over 21,000 people with ME/CFS and found 8 genetic regions tied to the illness.
These include genes linked to immune response and pain, helping confirm ME/CFS has both neurological and immunological roots.
research.ed.ac.uk/en/publication…
With just 4-6% of the Long COVID RECOVER funding we’d have managed to run a whopping 100,000 patients through the @amaticahealth RNA sequencing test.
And be well into subgrouping these patients & identifying treatment response predictors
They’ve achieved nothing with 100% of it
A new #PostCOVID / #LongCOVID single-arm study by ImmunityBio of Anktiva, an interleukin-15 receptor agonist which is used to treat bladder cancer.
20 patients will be enrolled at UCSF in San Francisco, with the study planned to start this month.
clinicaltrials.gov/study/NCT07108…
Amyloid microclots are implicated in #LongCOVID and other thrombo‑inflammatory diseases. These microclots persist in circulation and obstruct microvasculature, impair oxygen transport and promote chronic inflammation.
Conventional thrombolytic therapies such as recombinant…
A fascinating new study by Vishnu Shankar et al. @stanfordimmuno shows that oxidative stress is a shared characteristic of ME/CFS and Long COVID in lymphocytes due to inability to clear reactive oxygen species. This happens in sex-specific manner. (1/)
pnas.org/doi/abs/10.107…
BREAKING: Anecdotes are wonderful - let’s go get the data! Invivyd & leading researchers launch SPEAR Study Group to explore effects of mAb therapy on people suffering from Long COVID & post-vaccination syndrome. investors.adagiotx.com/news-releases/…@UCSF@polybioRF@MichaelPelusoMD…
149 Followers 3K FollowingCommentary & critique through a truthful lens on the dysfunction, corruption & failed leadership we couldn’t fix from within. Not affiliated with Cambridge Uni.
871 Followers 2K FollowingBarely living with #MECFS, and #ComplexChronicIllness including #PAIS #IACCs #CIRS #EDS #POTS #PSSD #TooTiredToThink #MUFC #Socialism
4K Followers 2K FollowingHealth & Medical Science (views my own) News and Research on #LongCovid #FBLC #MEspine #EDS Longhauler since March 2020, (3x Covid inf) #MECFS since 2011
317 Followers 408 FollowingCovid19 dès le 09/03/2020, pronostic vital engagé le 11/04/2020 pour atteinte cardiaque. Perte d'équilibre,essoufflement..ce virus a fait de ma vie un enfer !!!
17K Followers 468 FollowingDirector, Immunology Institute @SinaiImmunol @IcahnMountSinai | Harnessing the innate immune system for novel therapies against cancer & inflammatory diseases.
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1K Followers 42 FollowingData-informed advocacy to accelerate research on ME/CFS, Long COVID, and other infection-associated chronic conditions (IACCs) 💙
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635 Followers 807 FollowingProviding gold-standard rapid diagnostics that support personalised medicine and patient empowerment. RTs not an endorsement. Founder: @ProfAndrewShaw
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8K Followers 5K FollowingMild LC/ME Apr 2022 | ME, when triggered by SARS-CoV-2, is a subset of Long COVID | Repeated triggering of PEM leads to lowering of baseline | 🏳️🌈 | 🇮🇪
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