Stephanie Grebinoski @StephGrebinoski
Joined November 2019-
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Vignali and colleagues report CD8+ T cells in the pancreatic islets have a LAG3-promoted ‘restrained’ phenotype resembling exhausted cells but maintain effector functions, and LAG3 expression limits pathology in the NOD mouse model of type 1 diabetes rdcu.be/cOoL
I’m very excited to share my first, first author research paper with @Sherry_ZhangQZ! @Vignali_Lab @NatImmunol nature.com/articles/s4159…
Autoreactive intra-islet CD8+ T cells look exhausted (pheno/RNA/epige/meta), yet can be perturbed from their restrained state by ablation of LAG3. Thus, LAG3 limits autoimmunity and is a therapeutic target. @Vignali_Lab @StephGrebinoski QianxiaZhang nature.com/articles/s4159…
Excited to see this out! Kudos to @StephGrebinoski and @burkekelly1 for pulling this together and @JExpMed and @Gaia_JExpMed for the opportunity! @UPMCHillmanCC @Pitt_PMI #irAEs #cancerimmunotherapy #review
Excited to see this out! Kudos to @StephGrebinoski and @burkekelly1 for pulling this together and @JExpMed and @Gaia_JExpMed for the opportunity! @UPMCHillmanCC @Pitt_PMI #irAEs #cancerimmunotherapy #review
.@burkekelly1, @Vignali_Lab, @StephGrebinoski & Arlene Sharpe discuss several hypotheses regarding the underlying mechanisms of immune-related adverse events in #immunotherapy, the testing of which may improve #cancer patient outcomes. bit.ly/2K8nZOQ #JEMCancerFocus
Excited to share our latest review on inhibitory receptor agonists in Current Opinion in Immunology. Kudos to @StephGrebinoski! #IRs #Autoimmunity @Pitt_PMI @PittTweet nam05.safelinks.protection.outlook.com/?url=https%3A%…
At home, Pie are round. In math, Pi are squared
#ScienceMatters #FactsMatter Get it now??

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