Vincent Planche @VincentPlanche
Neurologist, Head of memory clinic, Bordeaux University Hospital. Associate Professor of Neurology, Bordeaux University, France Joined August 2017-
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Associations Between Blood-Based Biomarkers and Cognitive and Functional Trajectories Among Participants of the MEMENTO Cohort | Neurology neurology.org/doi/10.1212/WN…
Serum pTau-181 and nFL best predicted worsening cognition in those w subjective cognitive complaints or MCI, with serum amyloid having modest predictive value
Serum pTau-181 and nFL best predicted worsening cognition in those w subjective cognitive complaints or MCI, with serum amyloid having modest predictive value
🚨Paper Alert🚨 Excited to share our new piece with @MichalonRobin from @EHESS_fr @CAK_UMR While debates rage on following @alzassociation new #Alzheimer’s criteria we propose (Open Access) a historical perspective on what Alzheimer’s is. A thread👇🏻 1/21 onlinelibrary.wiley.com/doi/10.1111/en…
L’intelligence artificielle peut-elle nous ramener à la raison?
L’intelligence artificielle peut-elle nous ramener à la raison?
♥️
@MadhavThambiset @EWidera @smead2 @ajlees @ProfRobHoward @MemoryDoc @dr_shibley @LonSchneiderMD @seb_walsh @_michael_scholl @VincentPlanche @StefanoSensi14 @AlbertoEspay @nvillain_alz @KasperKepp @PhilAlz @Gill_Livingston @DrTFromKC @jfballenger @jasonkarlawish @JamesRuFletcher @AdamMBrickman @ManlyEpic @SFAckley @FortuneMagazine @TIME @ErinMPrater @TIMEMagazineRS @FT @hannahkuchler @CTADconference @NIH @alzassociation @howard_gleckman @AmerGeriatrics @kathy_y_liu @r_merrick @nlundebjerg @NathanielChinMD @US_FDA @NICEComms @RaymondKoopmans @MaastrichtU @Kariem_Ezzat @DrBenUnderwood1 @NHSEngland @ObserverUK @FeiiXiong @sducharme66 Explaining the Variability of Alzheimer Disease Fluid Biomarker Concentrations in Memory Clinic Patients Without Dementia neurology.org/doi/10.1212/WN… via @VincentPlanche et al
In the placebo-controlled LIXIPARK phase 2 trial involving persons with Parkinson’s disease, the subcutaneous GLP-1 receptor agonist lixisenatide was associated with reduced motor disability over a period of 12 months. Read the full trial results: nej.md/3J68HF8
The results of our nationwide study ‘ECASCAD’ on Alzheimer disease (AD) genetics are online! sciencedirect.com/science/articl… @GIMJournal 5 take-home messages:
[#PRESSE]"La prise en charge #Alzheimer avec le @CHUBordeaux" via @Bleu_Gironde 🧠ITW du Dr Vincent Planche, neurologue et responsable du Centre Mémoire Ressources Recherche du @CHUBordeaux ❔Accompagner un proche, diagnostic, hérédité... A écouter ici :francebleu.fr/emissions/les-…
“The process used to change the definition of #Alzheimer's disease serves as an exemplar of the insidious nature of how industry, including pharmaceutical and diagnostics corporations, influences how diseases are redefined.” #geriatrics #endalz. Read more: agsjournals.onlinelibrary.wiley.com/doi/full/10.11…
@VincentPlanche @ANAINFrance @JeunesGeriatres J’en profite pour mettre un lien vers cette revue pratico-pratique. Plus destinée aux soins primaires mais un peu de révisions ne fait jamais de mal ;) N’hésitez pas à me DM si intéressé(e)! Conduite à tenir devant une plainte mnésique larevuedupraticien.fr/article/condui… via @RevuePraticien
radical optimism @dr_shibley
29K Followers 22K Following #dementia #delirium #disability #neurodiversity primrose hill hon visiting prof @LivUni hon res fellow @ucl #cats #books pro #EU #ageing persl views
Andrew Kiselica, PhD,.. @AndrewK_PhD
2K Followers 1K Following Asst Prof and Neuropsychologist @Mizzou studying #Alzheimers and how technology can make life better for people with dementia and care partners | views my own
TNia @Dr_Tnia
3K Followers 4K Following Anatomist | Neuroscientist | Embryologist / IVF | Biologist | Anthropology | Evolution | Nature
Kasper Planeta Kepp @KasperKepp
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Chris Chatham @chchatham
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Chris O'Leary | The I.. @InnoTalker
140 Followers 288 Following Chris O'Leary is the host of the The Innovation Podcast (https://t.co/rHWOinI0EX) a deep dive into the HOW of Innovation, Entrepreneurship, science, and more.
Michael Schrift @mjschrift
55 Followers 947 Following Neuropsychiatrist/Geriatric Psychiatrist/Brain injury medicine/bioethics/neuroethics/Professor/Book review editorJNCN/all views are mine
Albert Vilella @AlbertVilella
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Josh Armstrong @josherArmstrong
884 Followers 2K Following Research Scientist at @AlzCanada. Interested in aging and analytics, but also fermentation and food. Tweets are my own.
Dr. Christine Miller @YTdementiadoc
74 Followers 445 Following Northerner. Care of the Elderly doc. Big on dementia, improving care for rural/remote older adults, reframing aging. Views my own.
Andreia Rocha @andreia_rocha_
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Overly Literate Skate.. @0xflashmine
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Bultingaire Vincent @BultingaireV
15 Followers 18 Following Gériatre Consultation mémoire de territoire EMG neuro comportementale Service de psychiatrie du sujet âgé Centre Hospitalier de Digne les Bains
Juliette Dunglas @JulietteDunglas
106 Followers 238 Following Journaliste santé/médical • Collectif @femmes2sante et @_AJSPI • Passée par @loctopusjournal, @GeriatriesFr & @CNRS
Dr. Jennifer Weuve @EpiDancer
3K Followers 365 Following professor of epidemiology @BUSPH #MELODEM #dementia #environment #epitwitter #AERoNOSE #ANDS #EpiCOVIDCorps #NotJen voc+keys in band w a rep old enough to vote
ponder @ponder39
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Mathieu Hainselin @MHainselin
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Yellow rose. @CherylRobe51121
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James @jameslimon__
166 Followers 467 Following bs psych @Official_UPD | @Neurasmus_ joint master in neuroscience @univbordeaux & @ChariteBerlin
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nono @n0emiebl
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Jamir Pitton Rissardo @theneurolander
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Zara @Zara091239
61 Followers 1K Following
Helena Gellersen @HGellersen
708 Followers 1K Following Postdoc at German Center for Neurodegenerative Diseases; Alzheimer’s, memory and the brain; PhD @Cambridge_Uni; also on @[email protected]
@marcusfitzsimons.bsk.. @MarcusFitzsimon
21K Followers 23K Following @marcusfitzsimons.bsky.social #ProgressiveAlliance #FBPA #FBPPR #FBPE #FBNHS #ScrapNHSBill #GTTO #Climate #FreePalestine. Be aware: Animal Lover. He him his
Eduardo Zimmer @erzimmer
4K Followers 3K Following PI @ufrgsnoticias @zimmerneurolab | Adjunct professor @mcgillu | Research associate @cerebro_rs | Interested in glia and neurodegeneration.
Federico Soria @SoriaFN
720 Followers 417 Following Neurobiologist @AchucarroGlia. Ramón y Cajal & Ikerbasque Researcher. Investigating matrix-microglia interplay in healthy and diseased brain. @GlioMatrixLab.🔬
Zac Green @ZacGreen24
276 Followers 466 Following M.D./Ph.D. Candidate. Aspiring Neuroscientist. He/him
Amrutha S @AMR_Neuro
17 Followers 280 Following Ph.D. Scholar cum JRF at Yenepoya Research Centre, Mangalore, India. Working on Neurodegenerative disorders: Alzheimer's & Parkinson's disease, an OMIC approach
Paul Maidowski @_ppmv
10K Followers 3K Following language, systems, climate policy. Fletcher/Fulbright d|e|f|i|中. Go(围棋) @ppmv.bsky.social https://t.co/Mqo4ELPYqB https://t.co/hiHp7ti0dm
Christian Limberger @limberger_chris
624 Followers 849 Following PhD Student @zimmerneurolab 🇧🇷 | Brain metabolism 🧠 | Astrocytes ⭐️ | Alzheimer’s disease
LSLS @Rudule1
5 Followers 76 Following
Lucía Crivelli @LuCrivelliOk
2K Followers 2K Following Neuropsychologist, PhD. || FLENI 🇦🇷 @FleniOficial || CONICET || LatAm FINGERS @LatamFingers
radical optimism @dr_shibley
29K Followers 22K Following #dementia #delirium #disability #neurodiversity primrose hill hon visiting prof @LivUni hon res fellow @ucl #cats #books pro #EU #ageing persl views
Andrew Kiselica, PhD,.. @AndrewK_PhD
2K Followers 1K Following Asst Prof and Neuropsychologist @Mizzou studying #Alzheimers and how technology can make life better for people with dementia and care partners | views my own
Suzanne E Schindler @SuzanneESchind1
766 Followers 270 Following Assoc Prof Neurology @WashUNeurology @WUADRC | Clinical neurologist and neuroscientist dedicated to improving the diagnosis and treatment of dementia.
What's up Doc @whatsupdoc_mag
16K Followers 864 Following On parle formation, hôpital, libéral, politique, e-santé. Bienvenue dans l’univers What's up Doc !
Grinberg Lab @GrinbergLab
277 Followers 8 Following The Grinberg Lab at the University of California, San Francisco investigates mechanisms of aging and neurodegenerative disease https://t.co/t9cxtolnnb
Dr. Jennifer Weuve @EpiDancer
3K Followers 365 Following professor of epidemiology @BUSPH #MELODEM #dementia #environment #epitwitter #AERoNOSE #ANDS #EpiCOVIDCorps #NotJen voc+keys in band w a rep old enough to vote
Olivier Véran @olivierveran
453K Followers 496 Following
SFGG @LaSFGG
4K Followers 2K Following Société Française de Gériatrie et Gérontologie / French Society of Geriatrics & Gerontology. "Comprendre et agir pour vieillir en bonne santé"
Asso Jeunes Gériatre.. @JeunesGeriatres
2K Followers 1K Following Association des Jeunes Gériatres | #jesuisgeriatre | Choisissez la gériatrie ! #LaGériatrieCEstSexy Bannière par https://t.co/rB9TVFZQM8
Pascoal Lab @LabPascoal
2K Followers 925 Following Lab based at University of Pittsburgh interested in diagnostic and therapeutic approaches in neurodegeneration | PI: @TharickAPascoal
European Academy of N.. @EANeurology
15K Followers 180 Following The EAN unites and supports neurologists across Europe.
Prof. Melissa E. Murr.. @DrNeuroChic
5K Followers 1K Following Translational neuropathologist | Biomarker enthusiast | Hopeful scientist | Scientific Program Committee @HAIconference #AAIC24 | Advisory board #ADPD2025
DZNE Research Center @DZNE_en
3K Followers 849 Following #Brain #Dementia #Parkinson Tweets: D. Bayer (db), M. Neitzert (mn) | Imprint https://t.co/ZS9f9GKIda Data privacy https://t.co/Um0J6WBCgb German @DZNE_de
Boris Mansencal @BorisMansencal
14 Followers 330 Following
Danielle Beckman @DaniBeckman
24K Followers 6K Following Neuroscientist working with primates 🐒. PharmD with an MS in Biophysics and a PhD in Biological Chemistry. Microscopy lover 🧠🔬 . #NeuroCovid is real.
Federico Soria @SoriaFN
720 Followers 417 Following Neurobiologist @AchucarroGlia. Ramón y Cajal & Ikerbasque Researcher. Investigating matrix-microglia interplay in healthy and diseased brain. @GlioMatrixLab.🔬
Eduardo Zimmer @erzimmer
4K Followers 3K Following PI @ufrgsnoticias @zimmerneurolab | Adjunct professor @mcgillu | Research associate @cerebro_rs | Interested in glia and neurodegeneration.
Zimmer Lab @zimmerneurolab
3K Followers 2K Following Multidisciplinary lab, at @ufrgsnoticias, interested in understanding neuron-to-astrocyte communication in neurodegenerative disorders 💜 | PI: @erzimmer
Aniket Mishra @AniketMishra87
133 Followers 431 Following Researcher (CDI-LRU, President/Chancellor nominated tenured position) in statistical genetics at the University of Bordeaux
Sant Pau Memory Unit @SantPauMemory
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Marc Suárez-Calvet �.. @M_SuarezCalvet
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Lille Neuroscience & .. @CognitionLille
819 Followers 168 Following Lille Neuroscience & Cognition #LilNCog est le centre de recherche Inserm en neurosciences de l'université de Lille sur le campus CHU (Directeur: @lucbuee )
Julie Gonneaud @julie_gonn
818 Followers 721 Following Neuroimaging & Neuropsychology | Ageing & Alzheimer's disease | 🍪
Wagner S. Brum @wagnersbrum
1K Followers 999 Following MD-PhD student working with Alzheimer's disease biomarkers and their clinical interpretation at @goteborgsuni @ufrgsnoticias @zimmerneurolab
Grinberg Lab UCSF @GrinbergLabUCSF
56 Followers 26 Following Dedicated to unravelling the mysteries of Alzheimer's disease and finding a cure since 2009
Morgane Linard @Morgane_Linard2
13 Followers 64 Following MD PhD - Postdoc in Epidemiology | @Inserm #bordeauxpopulationhealth @univbordeaux @Isped_Bordeaux #AlzheimerDisease #Club2ID Immunity, infection and dementia
Eric Widera, MD @EWidera
15K Followers 2K Following Professor of Medicine @UCSF. Focused on Geriatrics, Hospice, Palliative care, and medical education. Podcasts at https://t.co/U5ErQk8xvf
Cath Mummery🍊 @cathmummery
2K Followers 731 Following Head of Novel Therapeutics in dementia, Dementia Research Centre, UCL; Chair of NIHR dementia Translational Research Collaboration;
ANAINF @ANAINFrance
776 Followers 159 Following Association Nationale des Assistants et Internes en Neurologie de France 🧠 #NeurotwitterFR
Thomas Nedelec @thomas_nedelec
93 Followers 642 Following Externe de médecine (5eme année) / Ancien et toujours ingénieur / Post-doc @ICM sur les maladies du cerveau : on essaie de remonter le passé pour comprendre
Chloe James @chloe_james789
48 Followers 27 Following Professor of Hematology, Bordeaux University, Bordeaux University Hospital, Inserm 1034
Emmanuel Touzé @touze_emmanuel
746 Followers 477 Following Doyen UFR Santé Université Caen Normandie Président ONDPS Professeur de neurologie CHU Caen Normandie Consulting editor Stroke (AHA)
Olivier ROUAUD @orouaud1
186 Followers 912 Following #Neurologist, Leenaards Memory Centre @CHUVLausanne #Alzheimer #Dementia #Neuroscience #CTE interested in #Football and fan of @DFCO_officiel
David Wallon @davidwallon_
41 Followers 36 Following
Richard Bethlehem @rai_bethlehem
1K Followers 977 Following Assistant prof. in NeuroInformatics & Director of Neuroimaging at the Autism Research Centre both at @Cambridge_Uni also on @[email protected]
Agathe Vrillon @VrillonAgathe
100 Followers 127 Following MD, PhD, neurologist at @CNC_Alzheimer, @Inserm 🇫🇷 #biomarkers, Atlantic fellow for brain health #GBHI #UCSF
Gabor G. Kovacs MD Ph.. @GGKovacsBrain
741 Followers 218 Following Professor/University of Toronto & Consultant/University Health Network; Focus: Neuropathology/Neurology/Neurodegeneration Keywords: Nature/Compassion/Grit
The Lancet Healthy Lo.. @LancetLongevity
5K Followers 531 Following #LancetHealthyLongevity is an #OpenAccess journal from @TheLancet publishing clinically-focused #healthylongevity and #geroscience research + review #Lancet200
Adriano Aguzzi @AdrianoAguzzi
21K Followers 1K Following Physician, Prof of Neuropathology, mountain biker, prion researcher, https://t.co/p2LFL67xFj founder, Editor of @SwissMedWkly. Posts are orthogonal to my employer's.
Aurélien Rousseau @aur_rousseau
35K Followers 1K Following Ancien ministre de la santé et de la prévention ; élu de Saint-Hilaire-de-Brethmas, Gard.
Samieri Cecilia @CeciliaSamieri
34 Followers 34 Following
Dr. Axel Montagne, Ph.. @AxL_Montagne
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European Delirium @EDA_delirium
7K Followers 1K Following Promoting excellence in delirium research, practice and policy.
Marie-Claude Potier @McPotier
377 Followers 462 Following Observe, analyse and treat. Search answers for Down syndrome and Alzheimer’s
Tour de France™ @LeTour
3.2M Followers 1K Following 💛🏆 Jonas Vingegaard 🇩🇰 📅 #TDF2024 June, 29 - July, 21 🚴♀️ #TDFF2024 ➡ @LeTourFemmes
Marc Dhenain @mdhenain_cnrs
18 Followers 11 FollowingAssociations Between Blood-Based Biomarkers and Cognitive and Functional Trajectories Among Participants of the MEMENTO Cohort | Neurology neurology.org/doi/10.1212/WN…
So hard to keep colleagues, patients and the Alzheimer’s charities focussed on what the trial data actually show rather than what we’d all want to believe the drugs might be able to do.
Misleading to claim #donanemab or any amyloid lowering Rx will allow an #Alzheimer’s patient to continue to drive independently. Inserting the claim immediately outside a respected KOL’s quote also risks wrongly attributing this to them. Not a good look @ProfRobHoward @pash22
@Brain1878 Collection of some of our most stimulating recent papers on #Alzheimers disease now out academic.oup.com/brain/pages/al…
Happy to share our paper on atrophy heterogeneity in memory clinic settings – now online @Brain1878! This was a big one (started working on this on the first day of my PhD 👀), so let me walk you through it 🧵 [1/n] tinyurl.com/subtypesNstages @DZNE_en @biofinder_study @david_berron
@smead2 @VincentPlanche @TharickAPascoal @erzimmer @psanjua @zimmerneurolab @limberger_chris @Brain1878 There's no need to waste time on that: we're all very busy. I just enjoy chatting with you all on Twitter and asking questions to better understand "our" diseases
@TharickAPascoal @erzimmer @psanjua @zimmerneurolab @limberger_chris @Brain1878 What level of evidence are we discussing regarding the validation of blood GFAP? Mentioning other biomarkers is irrelevant to my current concern on GFAP (we still don't have good TDP43 biomarker but that's not a reason for making any lousy biomarker the new gold standard)
@erzimmer @psanjua @zimmerneurolab @limberger_chris @Brain1878 Thank you very much, Eduardo! Much appreciated! So, in short, do you agree that classifying Ast-/Ast+ based on serum GFAP would be incorrect from a biological point of view?
Serum pTau-181 and nFL best predicted worsening cognition in those w subjective cognitive complaints or MCI, with serum amyloid having modest predictive value
@PhilAlz @MadhavThambiset @EWidera @smead2 @ajlees @ProfRobHoward @MemoryDoc @dr_shibley @LonSchneiderMD @seb_walsh @_michael_scholl @VincentPlanche @StefanoSensi14 @AlbertoEspay @nvillain_alz @KasperKepp @Gill_Livingston @DrTFromKC @jfballenger @jasonkarlawish @JamesRuFletcher @AdamMBrickman @ManlyEpic @SFAckley @FortuneMagazine @TIME @ErinMPrater @TIMEMagazineRS @FT @hannahkuchler @CTADconference @NIH @alzassociation @howard_gleckman @AmerGeriatrics @kathy_y_liu @r_merrick @nlundebjerg @NathanielChinMD @US_FDA @NICEComms @RaymondKoopmans @MaastrichtU @Kariem_Ezzat @DrBenUnderwood1 @NHSEngland @ObserverUK @FeiiXiong @sducharme66 Associations Between Blood-Based Biomarkers and Cognitive and Functional Trajectories Among Participants of the MEMENTO Cohort neurology.org/doi/10.1212/WN… via @VincentPlanche et al
@NC_Renic "We can say with near certainty that this paper was not AI generated"
Editor: “please check the proofs carefully as this is the last opportunity to correct errors before publication” Academics: “yeah, looks sweet 🤘”
@VincentPlanche @CohortMemento @GreenJournal Very nice work!
@VincentPlanche @smead2 @SuzanneESchind1 @DrTFromKC @seb_walsh @pash22 @EWidera @ajlees @ProfRobHoward @MemoryDoc @dr_shibley @LonSchneiderMD @_michael_scholl @StefanoSensi14 @AlbertoEspay @nvillain_alz @KasperKepp @PhilAlz @Gill_Livingston @jfballenger @jasonkarlawish @JamesRuFletcher @AdamMBrickman @ManlyEpic @SFAckley @FortuneMagazine @TIME @ErinMPrater @TIMEMagazineRS @FT @hannahkuchler @CTADconference @NIH @alzassociation @howard_gleckman @AmerGeriatrics @kathy_y_liu @r_merrick @nlundebjerg @NathanielChinMD @US_FDA @NICEComms @RaymondKoopmans @MaastrichtU @Kariem_Ezzat @DrBenUnderwood1 @NHSEngland @ObserverUK @DavidJonesBrain I am going to steal this, Vincent! 😃
@smead2 @SuzanneESchind1 @DrTFromKC @seb_walsh @pash22 @EWidera @ajlees @ProfRobHoward @MemoryDoc @dr_shibley @LonSchneiderMD @_michael_scholl @VincentPlanche @StefanoSensi14 @AlbertoEspay @nvillain_alz @KasperKepp @PhilAlz @Gill_Livingston @jfballenger @jasonkarlawish @JamesRuFletcher @AdamMBrickman @ManlyEpic @SFAckley @FortuneMagazine @TIME @ErinMPrater @TIMEMagazineRS @FT @hannahkuchler @CTADconference @NIH @alzassociation @howard_gleckman @AmerGeriatrics @kathy_y_liu @r_merrick @nlundebjerg @NathanielChinMD @US_FDA @NICEComms @RaymondKoopmans @MaastrichtU @Kariem_Ezzat @DrBenUnderwood1 @NHSEngland @ObserverUK @DavidJonesBrain In case you missed it, Simon here’s the Alzforum story quoting two of the AA criteria panelists themselves alzforum.org/news/conferenc… Here is an excerpt 👇
@smead2 @MadhavThambiset @SuzanneESchind1 @DrTFromKC @seb_walsh @pash22 @EWidera @ajlees @ProfRobHoward @MemoryDoc @dr_shibley @LonSchneiderMD @_michael_scholl @VincentPlanche @StefanoSensi14 @AlbertoEspay @nvillain_alz @KasperKepp @PhilAlz @Gill_Livingston @jfballenger @jasonkarlawish @JamesRuFletcher @AdamMBrickman @ManlyEpic @SFAckley @FortuneMagazine @TIME @ErinMPrater @TIMEMagazineRS @FT @hannahkuchler @CTADconference @NIH @alzassociation @howard_gleckman @AmerGeriatrics @kathy_y_liu @r_merrick @nlundebjerg @NathanielChinMD @US_FDA @NICEComms @RaymondKoopmans @MaastrichtU @Kariem_Ezzat @DrBenUnderwood1 @NHSEngland @ObserverUK You must define the disease you are targeting with your criteria. A+ is not AD.
@DavidJonesBrain @MadhavThambiset @SuzanneESchind1 @DrTFromKC @seb_walsh @pash22 @EWidera @ajlees @ProfRobHoward @MemoryDoc @dr_shibley @LonSchneiderMD @_michael_scholl @VincentPlanche @StefanoSensi14 @AlbertoEspay @nvillain_alz @KasperKepp @PhilAlz @Gill_Livingston @jfballenger @jasonkarlawish @JamesRuFletcher @AdamMBrickman @ManlyEpic @SFAckley @FortuneMagazine @TIME @ErinMPrater @TIMEMagazineRS @FT @hannahkuchler @CTADconference @NIH @alzassociation @howard_gleckman @AmerGeriatrics @kathy_y_liu @r_merrick @nlundebjerg @NathanielChinMD @US_FDA @NICEComms @RaymondKoopmans @MaastrichtU @Kariem_Ezzat @DrBenUnderwood1 @NHSEngland @ObserverUK Well I would say obv important when using blood biomarkers not to turn your brain off and ignore all the things we have learned about sound diagnosis - history exam and all the other tools
@smead2 @MadhavThambiset @SuzanneESchind1 @DrTFromKC @seb_walsh @pash22 @EWidera @ajlees @ProfRobHoward @MemoryDoc @dr_shibley @LonSchneiderMD @_michael_scholl @VincentPlanche @StefanoSensi14 @AlbertoEspay @nvillain_alz @KasperKepp @PhilAlz @Gill_Livingston @jfballenger @jasonkarlawish @JamesRuFletcher @AdamMBrickman @ManlyEpic @SFAckley @FortuneMagazine @TIME @ErinMPrater @TIMEMagazineRS @FT @hannahkuchler @CTADconference @NIH @alzassociation @howard_gleckman @AmerGeriatrics @kathy_y_liu @r_merrick @nlundebjerg @NathanielChinMD @US_FDA @NICEComms @RaymondKoopmans @MaastrichtU @Kariem_Ezzat @DrBenUnderwood1 @NHSEngland @ObserverUK If you can say A+ does not mean AD. Then we are on the same page. If you think Thal phase 1 is AD we are not on the same page.
@DavidJonesBrain @smead2 @MadhavThambiset @SuzanneESchind1 @DrTFromKC @seb_walsh @pash22 @EWidera @ajlees @ProfRobHoward @MemoryDoc @dr_shibley @LonSchneiderMD @_michael_scholl @VincentPlanche @StefanoSensi14 @AlbertoEspay @KasperKepp @PhilAlz @Gill_Livingston @jfballenger @jasonkarlawish @JamesRuFletcher @AdamMBrickman @ManlyEpic @SFAckley @FortuneMagazine @TIME @ErinMPrater @TIMEMagazineRS @FT @hannahkuchler @CTADconference @NIH @alzassociation @howard_gleckman @AmerGeriatrics @kathy_y_liu @r_merrick @nlundebjerg @NathanielChinMD @US_FDA @NICEComms @RaymondKoopmans @MaastrichtU @Kariem_Ezzat @DrBenUnderwood1 @NHSEngland @ObserverUK It's getting even farther than Thal Ph1=AD. Thal and neuropath, generally speaking, only consider neuritic plaques, not diffuse plaques... Therefore, saying that A+ (all its dimensions) =AD is going too far: beyond what any nosologist (neuropath or clinician) has ever dared to go
@nvillain_alz @smead2 @MadhavThambiset @SuzanneESchind1 @DrTFromKC @seb_walsh @pash22 @EWidera @ajlees @ProfRobHoward @MemoryDoc @dr_shibley @LonSchneiderMD @_michael_scholl @VincentPlanche @StefanoSensi14 @AlbertoEspay @KasperKepp @PhilAlz @Gill_Livingston @jfballenger @jasonkarlawish @JamesRuFletcher @AdamMBrickman @ManlyEpic @SFAckley @FortuneMagazine @TIME @ErinMPrater @TIMEMagazineRS @FT @hannahkuchler @CTADconference @NIH @alzassociation @howard_gleckman @AmerGeriatrics @kathy_y_liu @r_merrick @nlundebjerg @NathanielChinMD @US_FDA @NICEComms @RaymondKoopmans @MaastrichtU @Kariem_Ezzat @DrBenUnderwood1 @NHSEngland @ObserverUK Yes. The logic of the new criteria has a floating definition of AD based on biomarker detection threshold of the “earliest possible pathophysiology”, by which they mean the amyloid pathway. Core 1 marks low to intermediate neuropath. So that’s AD for now.
@DavidJonesBrain @smead2 @MadhavThambiset @SuzanneESchind1 @DrTFromKC @seb_walsh @pash22 @EWidera @ajlees @ProfRobHoward @MemoryDoc @dr_shibley @LonSchneiderMD @_michael_scholl @VincentPlanche @StefanoSensi14 @AlbertoEspay @KasperKepp @PhilAlz @Gill_Livingston @jfballenger @jasonkarlawish @JamesRuFletcher @AdamMBrickman @ManlyEpic @SFAckley @FortuneMagazine @TIME @ErinMPrater @TIMEMagazineRS @FT @hannahkuchler @CTADconference @NIH @alzassociation @howard_gleckman @AmerGeriatrics @kathy_y_liu @r_merrick @nlundebjerg @NathanielChinMD @US_FDA @NICEComms @RaymondKoopmans @MaastrichtU @Kariem_Ezzat @DrBenUnderwood1 @NHSEngland @ObserverUK Absolutely! Biomarker sensitivity limits access to earliest stages. However, as you say, the theory is "Our position is that the onset of β-amyloidosis defines the initially detectable stage of AD" Improved biomarker sensitivity will enable diagnosing Thal Phase 0a in the future
@jasonkarlawish @MadhavThambiset @nvillain_alz @DavidJonesBrain @smead2 @SuzanneESchind1 @DrTFromKC @seb_walsh @pash22 @EWidera @ajlees @MemoryDoc @dr_shibley @LonSchneiderMD @_michael_scholl @VincentPlanche @StefanoSensi14 @AlbertoEspay @KasperKepp @PhilAlz @Gill_Livingston @jfballenger @JamesRuFletcher @AdamMBrickman @ManlyEpic @SFAckley @FortuneMagazine @TIME @ErinMPrater @TIMEMagazineRS @FT @hannahkuchler @CTADconference @NIH @alzassociation @howard_gleckman @AmerGeriatrics @kathy_y_liu @r_merrick @nlundebjerg @NathanielChinMD @US_FDA @NICEComms @RaymondKoopmans @MaastrichtU @Kariem_Ezzat @DrBenUnderwood1 @NHSEngland @ObserverUK I foresee chaos in the subjective cognitive complaints/functional cognitive disorder group if any biomarker is positive. If negative, this would be highly useful, of course.
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