William Aird @WilliamAird4

Professor of Medicine at Harvard Medical School #Hematology #MedEd Founder of @TheBloodProjec1 Boston, MA Joined August 2021

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William Aird @WilliamAird4

7 days ago

ANEMIA OF INFLAMMATION In anemia of inflammation (AI), hemoglobin falls but rarely below ~8 g/dL, an evolutionary floor that withholds iron from pathogens while preserving host viability. See attached infographic for more information about AI.

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William Aird @WilliamAird4

5 days ago

IT TAKES A VILLAGE TO MAKE A RED CELL Oxygen and Fe balance is a team sport: kidney (EPO), marrow (RBCs + ERFE), liver (hepcidin), gut (iron). A whole-body conversation we rarely talk about - usually reduced to a series of ‘feedback loops’, which focus on mediators, not organs

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William Aird @WilliamAird4

a week ago

SPLENOMEGALY AND HYPERSPLENISM Correction: 80-90% of splenic blood flow traveling through the open circulation and 10-20% through the closed circulation, not the other way around (corrected graphic below). Want to learn more? Check out: thebloodproject.com/hypersplenism/

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William Aird @WilliamAird4

a week ago

1/5 SPLENOMEGALY/HYPERSPLENISM Mechanisms of splenomegaly: • Congestive • Work hypertrophy • Infiltrative What enlarges? • Red pulp: macrophages, sinusoids, blood • White pulp: lymphocytes, plasma cells • Infiltrative: tumor, storage cells, granulomas, amyloid #MedEd

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William Aird @WilliamAird4

2 weeks ago

Recent Poll on Anticoagulation (AC) After Filter Placement 91% got it right! CPGs recommend restarting AC: With the filter in place, anticoagulation should be resumed as soon as it becomes safe. This minimizes the risk of recurrent VTE and filter-related thrombosis.

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William Aird @WilliamAird4

2 weeks ago

RBC as Factory Analogy A red blood cell is like a stripped-down factory: no power plant (mitochondria) and no blueprint office (nucleus) to store DNA and send out RNA instructions to repair or make new machines. Just the machines on the floor, running until they wear out.