Alex Lercher @alex_lercher

Immunologist | HFSP Postdoctoral Fellow @RiceLaboratory | PhD @bergthalerlab | opinions are my own. find me on @alercher.bsky.social New York, USA Joined December 2013

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Alex Lercher @alex_lercher

2 months ago

Extremely happy to be awarded the Sidney & Joan Pestka Post-graduate award! Thank you @CytokineSociety and all my mentors, colleagues and collaborators throughout my career so far!

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Location, infection history, antigen persistence shape the tissue-resident T cells (Trm), challenging the idea of a universal framework for Trm identity across organs and diseases. High/low antigen immunogenicity may add another layer... @ImmunityCP tinyurl.com/49dkc3j7

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Alex Lercher @alex_lercher

9 months ago

A commensal bacterium triggers systemic antibody responses via skin lymphoid structures and can be engineered as a topical vaccine – great therapeutic potential! Two studies in @Nature by @mfgrp and @BelkaidLab tinyurl.com/5yahn47t tinyurl.com/4n4btxap

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Alex Lercher @alex_lercher

9 months ago

Great Spotlight by @VirusesImmunity and @S_Tabachnikova on our recent publication in @ImmunityCP, where we studied antiviral innate immune memory in alveolar macrophages in the context of respiratory viral infections! cell.com/trends/immunol…

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Alex Lercher @alex_lercher

10 months ago

If you are an auditory person – TWIV discussed our recent paper on innate immune memory in sequential respiratory viral infections. Paper review starts at 37:00, more general discussion and broader implications at 1:10:00. open.spotify.com/episode/777wxT… @profvrr @ImmunityCP

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Alex Lercher @alex_lercher

10 months ago

Chronic autoimmunity rewires metabolism in progenitors, correlating with innate immune memory formation in macrophages that increases antibacterial activity but might also aggravate autoimmune diseases? shorturl.at/SZ1Ww @CellStemCell @pietras_eric @Taylor_S_Mills

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Alex Lercher @alex_lercher

10 months ago

The sky is always bluer on the other side - give me a follow if you would like to stay connected via alercher.bsky.social

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Alex Lercher @alex_lercher

10 months ago

Our article on antiviral innate immune memory and alveolar macrophages made the cover of @ImmunityCP Check out the full article here: shorturl.at/tArb0

Immunity @ImmunityCP

10 months ago

Our article on antiviral innate immune memory and alveolar macrophages made the cover of @ImmunityCP Check out the full article here: shorturl.at/tArb0

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Alex Lercher @alex_lercher

a year ago

Had a great time presenting our work on antiviral innate immune memory! Thanks to @HFSP for the opportunity and support of this project! Link to the initial version of the manuscript: biorxiv.org/content/10.110…

HFSP @HFSP

a year ago

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Julia S. Brunner @jules_stef

2 years ago

Thank you @NatureComms for publishing my first paper and asking me about the slightly turbulent back story! nature.com/articles/s4146…

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Alex Lercher @alex_lercher

3 years ago

Sub-cutaneous BCG vaccination induces 𝙞𝙣𝙣𝙖𝙩𝙚 𝙞𝙢𝙢𝙪𝙣𝙚 𝙢𝙚𝙢𝙤𝙧𝙮 in alveolar macrophages via altered metabolite output of the gut microbiota. In fact, dietary supplementation of butyrate is sufficient! @NatImmunol nature.com/articles/s4159…

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Alex Lercher @alex_lercher

3 years ago

Great review by @jules_stef and @lydfinley on how 𝙢𝙚𝙩𝙖𝙗𝙤𝙡𝙞𝙘 𝙥𝙧𝙤𝙜𝙧𝙖𝙢𝙨 influence basic decision points of cell identity like self-renewal vs proliferation – makes me want to give my current project a metabolic twist! @NatureRevEndo rdcu.be/c0DRI