Anders J. Skanderup @anders_js
Computational cancer genomics skandlab.org Genome Institute of Singapore Joined April 2010-
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✨Highlighting a @CD_AACR Special Issue Commentary for #AACR24: Precision Endpoints for Contemporary Precision Oncology Trials - by Regina Hoo, @drkevin_chua_lm, @pankajpanda86, @anders_js, & @danieltanmd doi.org/10.1158/2159-8…
Really clever approach to help understand the impact of broad copy number changes: Cancer aneuploidies are shaped primarily by effects on tumour fitness nature.com/articles/s4158…
Can AI help predict pancreatic cancer earlier? nature.com/articles/s4159… and hms.harvard.edu/news
Go cBioPortal ! Lots of new features for easy analytic access to cancer genomics, proteomics and more. Make your own discoveries on community-provided cancer data and analysis tools.
Go cBioPortal ! Lots of new features for easy analytic access to cancer genomics, proteomics and more. Make your own discoveries on community-provided cancer data and analysis tools.
PUREE is a weakly supervised machine learning algorithm that can accurately infer tumor purity from bulk tumor gene expression data: doi.org/10.1038/s42003… @anders_js, @RevkovEgor
Today our important study on air pollutants in the promotion of lung cancer has been published in @Nature led by @WillHilliam @LimEmilia @DrClareWeeden @SwantonLab ...Thread below🧵nature.com/articles/s4158…
#Fluoxetine (#Prozac) changes so many genes in so many brain regions. Mechanism(s) of action are dizzyingly complex, but some promising themes emerge👇. Long-term collab with @meaneylab et al. Large integrative omics study heroically led by @braincrank_nr. @astar_gis #depression
#Fluoxetine (#Prozac) changes so many genes in so many brain regions. Mechanism(s) of action are dizzyingly complex, but some promising themes emerge👇. Long-term collab with @meaneylab et al. Large integrative omics study heroically led by @braincrank_nr. @astar_gis #depression
Singapore scientists develop AI-based method to identify cancer mutations buff.ly/3pSJLaf
To update the classification system for #colorectal #cancer, the team analysed 373,000 #singlecells from 141 #tumour samples collected frm 63 patients in SG, BE, S KR. Read: clinicalresearchnewsonline.com/news/2022/08/1…
1 of the deadliest cancers with diverse etiological factors worldwide. We found unprecedented genomic diff. segregating distinctively across ethnicities & stressed the importance of differential disease biology & management in HCC across ethnicities. thno.org/v12p4703.htm
Our recent preprint trying to explore the tricky question of “blood microbiome”! Great work by an amazing intern in the lab @cedriccstan guided by @minghao_chia biorxiv.org/content/10.110…
Our recent preprint trying to explore the tricky question of “blood microbiome”! Great work by an amazing intern in the lab @cedriccstan guided by @minghao_chia biorxiv.org/content/10.110…
VarNet, a weakly supervised #deeplearning model for somatic #VariantCalling in cancer that does not require human-engineered features or heuristic filters #CancerResearch by @anders_js @kiran__chari et al. go.nature.com/3opGfDM
‼️ OUT TODAY @NatureGenet 📰 Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer 🧑🏿🤝🧑🏼 @iaintan_mdphd @shyam_lab @astar_gis and colleagues 👇🏿 go.nature.com/3bI7ZA8
Excited to share our new study and resource on tumor metabolism with @rohatgineha @astar_gis. Using tumor transcriptome deconvolution, we identify metabolic differences of cancer and stromal cells inside tumors. Some expected and unexpected findings ... doi.org/10.1016/j.celr…
Those signatures that were reported in that amazing 18k WGS analysis paper in Science yesterday? They can all be browsed on the amazing Signal resource portal! signal.mutationalsignatures.com. 😎
Effective drug combinations in breast, colon and pancreatic cancer cells. 2025 drug combinations vs 125 cancer cell lines 😮nature.com/articles/s4158…
Wonderful portal that enables exploration of the phenomenal Hartwig metastatic cancer WGS/RNAseq cohort.
Wonderful portal that enables exploration of the phenomenal Hartwig metastatic cancer WGS/RNAseq cohort.
Collaboration with Sjoerd van Hagen, Sander Rodenburg and Elena Garcia Lara @TheHyveNL and Augustin Luna @canninl - more to come as CPTAC enters its next phase. Go proteomics in cancer profiling!
Collaboration with Sjoerd van Hagen, Sander Rodenburg and Elena Garcia Lara @TheHyveNL and Augustin Luna @canninl - more to come as CPTAC enters its next phase. Go proteomics in cancer profiling!
Excited that our paper is online! Highlights how pervasive lineage transition occurs at a transcriptomic level in T790M neg resistance, suggesting the potential for tissue-based integrative analysis to forecast resistance trajectories in EGFR M+ NSCLC. clincancerres.aacrjournals.org/content/early/…
New paper by @anders_js @GuanhuaPeterZhu @astar_gis shows that nucleosome-dependent degradation and 6 regulatory regions are predictive of #circulating #tumour #DNA burden throughout #cancer #progression #cancerResearch @NatResCancer go.nature.com/3uSbKYl

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nature @Nature
2.6M Followers 3K Following Research, News, and Commentary from Nature, the international science journal For daily science news, get Nature Briefing: https://t.co/wGmQlQ8a4D
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