Jonathan Loree @jonathanloree
GI Medical Oncologist at BC Cancer, Associate Professor at The University of British Columbia, Senior Investigator at the Canadian Cancer Trials Group (CCTG) Vancouver, British Columbia Joined March 2014-
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Impact of Human Epidermal Growth Factor Receptor 2 in Patients With Metastatic Colorectal Cancer Treated With Chemotherapy Plus Bevacizumab or Anti-EGFRs: Exploratory Analysis of Eight Randomized Trials | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JC…
Exciting science and clinical efficacy in this @MDAndersonNews team science study led by @VanMorrisMD In Cancer Cell. Triple therapy with IO led to durable responses in BRAF V600E MSS colorectal cancer, showing promise. Randomized study ongoing. #crcsm cell.com/cancer-cell/fu…
Liquid biopsies in #CRC 🩸 Serial MRD monitoring: ✔️Detects recurrence 8–11 months earlier than imaging ✔️Improves sensitivity from 40–50% to 80–90% ✔️Helps monitor ACT response Liquid tumor-agnostic assays are evolving: now integrating ✅Methylation ✅Fragmentomics…
What if this was a drug ?🙂 🆕 NEJM | June 2025 🎯 CHALLENGE Trial: Structured exercise after adjuvant chemo in colon cancer 📦 RCT | n=889 | Median FU: 7.9 yrs 🟠 3-yr structured aerobic program vs health ed alone 📈 Primary Endpoint: Disease-Free Survival (DFS) 🔹 HR 0.72…
Both hand cooling and compression were effective in preventing sensory chemotherapy-induced peripheral neuropathy during taxane-based chemotherapy. ja.ma/4ih0UDi @MBreckwoldt
Cell-free DNA (cfDNA) testing could improve colorectal cancer detection and reduce mortality in Canada, but it requires higher participation rates to be effective compared to current screening methods. ja.ma/4lUmTD1 @jonathanloree
New research: Neoadjuvant chemoradiotherapy followed by active surveillance versus standard surgery for #oesophagealcancer (SANO trial): a multicentre, stepped-wedge, cluster-randomised, non-inferiority, phase 3 trial thelancet.com/journals/lanon…
Just published in @JCO_ASCO the updated @ASCO guidelines on fertility preservation in people with #cancer: a must read for all colleagues involved in cancer care to increase awareness on #oncofertility issues @OncoAlert @AnnPartridgeMD @oncofertility Link: ascopubs.org/doi/10.1200/JC…
#GI25 ❤️ @ASCO So proud to see our past and present #oncology trainees thriving & making their mark! @jaypsv @jonathanloree @yeung_cynthia @howiel2013 🇨🇦 @BCCancer @UBCmedicine
@NCICTEP_ClinRes @SWOG @CDNCancerTrials #Coloncancer Task Force Chairs @smitha42 @jonathanloree hard at work at Oral Presentation session @ASCO #ASCOGI25 analyzing the LBA’s including BREAKWATER, CALGB80702, BESPOKE and CM 8HW. 👏 👏 💪💙
🔥off the press: The use of immunotherapy pre-liver transplant @JHepatology authors.elsevier.com/c/1kNgCcOnAUhMK 👉Hepatology Snapshot 👉Our thoughts on the use of ICI before liver transplant in HCC 👉Food for thoughts.. @myESMO @EASLedu @ILCAnews #livertwitter
Recently published: #ClonalHematopoiesis of Indeterminate Potential (CHIP) & Its Association with Treatment Outcomes & Adverse Events in Patients with Solid Tumours. doi.org/10.1158/2767-9… @jonathanloree @jaypsv @rob_vanner @PancreasBC @BCCancer #openaccess
Nice to see CM8HW in press! @NEJM 📌 n=303 centrally confirmed dMMR mCRC 1L ➡️ 2y PFS 72% nivo-ipi vs 14% chemo 🌟 Per earlier BMS release, combo is superior to nivo arm but awaiting data - in whom? by how much? toxicity diff? ❓How do we identify pts w/dMMR mCRC who may still…
Nice to see CM8HW in press! @NEJM 📌 n=303 centrally confirmed dMMR mCRC 1L ➡️ 2y PFS 72% nivo-ipi vs 14% chemo 🌟 Per earlier BMS release, combo is superior to nivo arm but awaiting data - in whom? by how much? toxicity diff? ❓How do we identify pts w/dMMR mCRC who may still… https://t.co/gt0BthlghF
Joint #CommNETs & @NANETS1 guidance document on treatment informing features in NETs. Supplements loaded with comprehensive reviews of data for each biomarker (highlights where we need to generate data!) and patient education document co-developed with @CNETSCanada @NECancerAus
Joint #CommNETs & @NANETS1 guidance document on treatment informing features in NETs. Supplements loaded with comprehensive reviews of data for each biomarker (highlights where we need to generate data!) and patient education document co-developed with @CNETSCanada @NECancerAus
🔥of the press Neoadjuvant nivolumab and relatlimab in locally advanced MMR-deficient colon cancer: a phase 2 trial @NatureMedicine 👇doi.org/10.1038/s41591… @myESMO #ESMOAmbassadors #ESMO24
Vitamin D with CTx + bevacizumab in previously untreated mCRC #ESMO24 🔎SOLARIS (Alliance A021703) 👉ORR 51 vs 44% 👉mPFS 11.8 vs 10.3 mo, benefit for left-sided tumors? 👉mOS 25.6 vs 27 mo 👉AE ≥3 no difference 🧐🚫trial, no benefit for Vit D.. @myESMO #ESMOAmbassadors
NEO outcomes min 3 yr f/up presented at #ESMO2024 ! Neoadj FOLFOX/CAPOX + TES great for organ preserv’n in early rectal cancer: -LR 7.1% and 100% OS at 3 yr -LARS score unchanged from baseline -RT still an option for recurrence or 2nd pelvic CA @HKennecke @CDNCancerTrials

Sharlene Gill, MD, MP... @GillSharlene
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#CRCTrialsChat @CrcTrialsChat
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Shaalan Beg MD MBA FA... @ShaalanBeg
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Canadian Association ... @CAMO_ACOM
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World Journal of Onco... @WJON_Journal
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Assemble Universal Pa... @UniversalPannel
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Sharlene Gill, MD, MP... @GillSharlene
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ASCO @ASCO
149K Followers 2K Following Account of the American Society of Clinical Oncology & its affiliate the Association for Clinical Oncology. Assoc tweets labeled #ASCOAdvocacy. RTs ≠ endorse.
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Research at Canadian ... @CCSResearch
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120K Followers 270 Following Updates, news and prevention tips from the BC Wildfire Service. Report wildfires to *5555 on a cell or 1 800 663-5555 toll-free.
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The Vancouver Sun @VancouverSun
300K Followers 969 Following Western Canada's largest news team. Send tips to [email protected]. Sign up for our free newsletters here: https://t.co/8UXVB7PQVH
aavina @aavina100
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