Mohammad Kawsar Manik @manikrpc

Structure biologist and biochemist. 🇧🇩 🇰🇷 🇦🇺 🇺🇸| Views are my own. Brisbane, CA Joined April 2013

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293
Following

814
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863

Cell Host & Microbe @cellhostmicrobe

2 months ago

Phage DNA modifications evade defense: Phage DNA modification adds arabinose to cytosines via hydroxy linkage(5ara-hC) w/potential double & triple arabinosylation. Arabinosylated phages are protected from DNA-targeting CRISPR-Cas & restriction modification cell.com/cell-host-micr…

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Cristiano Ronaldo @Cristiano

3 months ago

This chapter is over. The story? Still being written. Grateful to all.

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Dziugas Sabonis @d_sabonis

4 months ago

Excited to share our latest on the Type II Thoeris system! In collaboration with the Sorek and Kranzusch labs, we identify His-ADPR as a signaling molecule. Huge thanks to all involved—amazing teamwork! nature.com/articles/s4158…

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Mitchell Sorbello @MitchellSorbel2

6 months ago

Plant TIR domains are the coolest TIR domains! Privileged to be a part of this work, that is up on bioRxiv. biorxiv.org/content/10.110… @Kobe_Lab_

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Adam Bentham @AdamRBentham

6 months ago

Pls RT 🚨I'm looking for someone excited about #proteindesign and #synbio to join my lab @durham_uni and the @CPBM_heddlelab to undertake a PhD using #synthetic knottins as novel #bioinsecticides. If you're interested please get in touch and check out the advert below 👇

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Jonathan Kagan @jkagan1

7 months ago

This is a list of blockbuster drugs in 2024. Guess how many can trace their origins to NIH funded research? All of them.

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Dr. Lucky Tran @luckytran

7 months ago

The NIH announced it will slash billions of dollars of support to universities and research centers. This is one of the biggest attacks on science we have ever seen. It could dismantle the biomedical research system, shut down clinical trials, and halt development of treatments.

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F. Perry Wilson, MD MSCE @fperrywilson

7 months ago

NIH has announced a cut in the "indirect rate" to 15% across the board, in a move that appears to be retroactive to even existing grants. This is a bloodbath for research institutions throughout the country. Brief explainer for those not in this world: buff.ly/3EtML7D

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Sorek Lab @SorekLab

7 months ago

Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems CARDs are essential for caspase recruitment in inflammasome activation. We now find them in bacterial immune systems Congrats @TanaWein! Thanks Kranzusch lab! tinyurl.com/CA88DD

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Luke de Pulford @lukedepulford

7 months ago

Just fyi, @deepseek_ai collects your IP, keystroke patterns, device info, etc etc, and stores it in China, where all that data is vulnerable to arbitrary requisition from the 🇨🇳 State. From their own privacy policy:

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Erez Tzvi Yirmiya @ErezTzvi

8 months ago

I'm thrilled to announce our latest work is now published in Cell! Viruses encode numerous proteins that inhibit host defenses, but identifying immune-modulatory proteins among millions of viral sequences has been nearly impossible - until now! cell.com/cell/fulltext/…

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Kobe Lab @Kobe_Lab_

8 months ago

Excited to share our work in @PNASNews . We report the cryoEM structures of both TRIF and TRAM uncovering the molecular basis of TRIF-mediated TLR3 and TLR4 signalling pathways. pnas.org/doi/10.1073/pn…

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Ryan Potts @pottslab

11 months ago

Vividion CRL3-KEAP1 covalent allosteric glue that stabilizes the Ligase complex to allow NRF2 degradation. biorxiv.org/content/10.110…

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Stephen Tang @stephentang23

11 months ago

Thrilled, and also in a bit of disbelief, to see our paper featured on the cover of @ScienceMagazine! "Finding Neo" wasn't easy, but we just kept swimming (read: stared at a sequence of DNA) until the Eureka moment hit.

Science Magazine @ScienceMagazine

11 months ago

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Anna Greka @AnnaGreka

12 months ago

Delighted to share our latest @GrekaLab story in collaboration with @WuLabHarvard on the molecular basis of TMED9 cargo receptor oligomerization and entrapment of misfolded cargo in the early secretory pathway. @broadinstitute @harvardmed @MassGenBrigham science.org/doi/10.1126/sc…

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Kobe Lab @Kobe_Lab_

a year ago

We’re #hiring! A #postdoc is available in Kobe lab to work on structure-guided inhibitor design of proteins involved in immune system. See job advertisement at uq.wd3.myworkdayjobs.com/en-US/uqcareer…. Apply by 13th August 2024 11:00 pm. #structuralbiology #drugdesign

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Prof. Hao Wu @WuLabHarvard

a year ago

Exited to share our new paper by Gang Du @ , Liam @L_Heals, Liron David @LironDavid2 and others on GSDMD palmitoylation. “ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D” in Nature nature.com/articles/s4158…. Even full-length GSDMD can form pores!

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Mohammad Kawsar Manik @manikrpc

2 years ago

Nice work!

Giedre Tamulaitiene @eigie111

2 years ago

Nice work!

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Michael Landsberg ❄️⚛️🔬 @buffalo_berger

2 years ago

This is how you level up your visualisation game.

Alex J Noble @alexjamesnoble

2 years ago

This is how you level up your visualisation game.

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Jonathan Kagan @jkagan1

2 years ago

STING is a membrane channel. Findings help explain why STING has all those transmembrane domains, a question that has puzzled many (including me) for years. Kudos to Hacohen, Irvine and Bingxu Liu on this interesting discovery. @BingxuL @MIT lnkd.in/eQ6TXhvr