Matthew Stoker @matthewbstoker
He/him. Interests in Global Health, Critical Care, Immunology, Virology, Vaccinology, Global Epi and Malnutrition, RPCV Maternal & Child Health Guatemala Tucson, Arizona Joined October 2009-
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The H5N1 strain (A/Texas/37/2024) circulating in cows has not gained effective binding for ⍺-2,6 sialic acid receptors common in humans, but it has gotten better at binding to different types of ⍺-2,3 receptors. May explain increased host range of this virus.
The H5N1 strain (A/Texas/37/2024) circulating in cows has not gained effective binding for ⍺-2,6 sialic acid receptors common in humans, but it has gotten better at binding to different types of ⍺-2,3 receptors. May explain increased host range of this virus.
CDC details that all 3 spillovers involved direct contact with sick cows. Very much looks like a risk that can be mitigated with appropriate PPE, though unclear how much, if any, PPE dairy farm workers are using. Some dairy farmers may not be testing their cows enough or at all
CDC details that all 3 spillovers involved direct contact with sick cows. Very much looks like a risk that can be mitigated with appropriate PPE, though unclear how much, if any, PPE dairy farm workers are using. Some dairy farmers may not be testing their cows enough or at all https://t.co/lIVt98fivA
Per CDC, A/Texas/37/2024 hasn't yet evolved to effectively bind human hemagglutinin receptors, as opposed to its well established ability to bind avian receptors. No doubt, this type of surveillance should be continued given the ongoing spread of this virus.
Per CDC, A/Texas/37/2024 hasn't yet evolved to effectively bind human hemagglutinin receptors, as opposed to its well established ability to bind avian receptors. No doubt, this type of surveillance should be continued given the ongoing spread of this virus. https://t.co/uS9lDDC0R9
A lot of unknowns how H5N1 spread between dairy farms. Certainly not impossible that some spread through the air may have occurred. Due to a lack of research and ability to gather said research, we really have no idea how the herds became infected or when it might end.
A lot of unknowns how H5N1 spread between dairy farms. Certainly not impossible that some spread through the air may have occurred. Due to a lack of research and ability to gather said research, we really have no idea how the herds became infected or when it might end. https://t.co/8fYe6GUFuQ
USDA indicates that spread of H5N1 among dairy cows is likely multifactorial (employees who work on different dairies/veterinarians/equipment) and can't be stopped solely by isolating herds, aphis.usda.gov/sites/default/…. Dashes hope that H5N1 infection of herds can be easily stopped.
A big reason why H5N1 has not entered the human population is because humans are more hygienic that wild mammals (we generally don't eat uncooked wild birds), with the notable exception of consumption of raw milk, medicalxpress.com/news/2024-06-b…. FDA is working to address this risk.
A child who was hospitalized in Australia with H5N1 had a recent travel history to India where she may have contracted the virus, reuters.com/world/asia-pac…. No known exposures to animals or infected people.
USDA is working towards avoiding that H5N1 does not become endemic in US dairy cows, thefern.org/ag_insider/usd…, major obstacles are the lack of widespread testing, longstanding persistence of H5N1 in birds and ability of this virus to jump to different mammalian species.
$824 million in funding for the H5N1 situation in dairy cows. Effective #H5N1 vaccines for farm animals (dairy cattle and pigs included) would help to provide epidemiological control. texasfarmbureau.org/usda-provides-…
The first Michigan H5N1 case involved a 'splash of infected milk' and produced only eye symptoms; now, 'direct exposure' (just being around an infected cow, not necessarily just raw milk I'm assuming) can lead to H5N1 infection with respiratory symptoms. cnn.com/2024/05/30/hea…
Possible that come winter, you could see increased/continued H5N1 spillovers to farmworkers, and also you'll have seasonal influenza circulating, could see reassortment in humans or other species between seasonal flu and H5N1. Mutations a risk just because so much H5N1 out there
Possible that come winter, you could see increased/continued H5N1 spillovers to farmworkers, and also you'll have seasonal influenza circulating, could see reassortment in humans or other species between seasonal flu and H5N1. Mutations a risk just because so much H5N1 out there
Third case of H5N1 from infected cows, more than just the conjunctivitis of prior cases, the 3rd case had URI symptoms including cough. A lot went right including isolating at home, monitoring of household contacts and additional genetic analysis pending.
Federal government nearing deal to fund trial of Moderna H5N1 vaccine, reuters.com/business/healt…. At the very least, we'll get immunogenicity data on an mRNA flu vaccine, could go into mass production if rapid scale-up of H5N1 vax is needed.
Agree 100% that H5N1 should be eradicated from the cow population, work has begun on a candidate vaccine, science.org/content/articl…. More testing and isolation of affected herds could help. Endemic H5N1 means ongoing spillover and risk of a pandemic.
Agree 100% that H5N1 should be eradicated from the cow population, work has begun on a candidate vaccine, science.org/content/articl…. More testing and isolation of affected herds could help. Endemic H5N1 means ongoing spillover and risk of a pandemic.
CDC health advisory: emergency.cdc.gov/han/2024/han00…, increase in N. Meningitidis serogroup Y, often atypical presentation with bacteremia/septic arthritis, 30-60 y/o, African Americans, and patients with HIV most affected.
Prety amazing Post-Partum Hemorrhage trial, nejm.org/doi/full/10.10…, may become standard of care everywhere, decreased PPH risk by using a calibrated blood drape and a bundle of 1st response interventions: uterine massage, oxytonic meds, TXA, IVFs, exams & care escalation.
Encouraging First-in-Human Results for a Promising HIV Vaccine directorsblog.nih.gov/2023/06/06/enc… , the big hope is that induction of broadly neutralizing antibodies before HIV infection will be effective, future vaccine will aim to induce an immune response in helper T cells as well.
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