Pramalkumar Patel @pramalpatel
Ph.D. Candidate (Maxwell Lab), University of Toronto 🇮🇳🇨🇦. Studying the arms race between bacteria and phages. Toronto, Ontario Joined January 2020-
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Happy to share our new preprint describing prophage encoded anti-phage defense system,TERi, that targets the terminase complex of invading phages to inhibit DNA packaging. The system also encode self immunity proteins that protect the prophage. biorxiv.org/content/biorxi…
Our paper out @CellCellPress: Structure-guided discovery of viral proteins that inhibit host immunity Congrats @ErezTzvi, Azita Leavitt, @amitai_gil, our collaborators @ Kranzusch lab, and coauthors A 🧵 1/10 cell.com/cell/abstract/…
Did you know that bacteria remember their past for many generations? In this new preprint from us (@VillaniAlexis and Senen Mendoza) and Banin lab (@ShmidovE ), we reveal the "how?" and "why?" underlying a long-standing mystery in bacterial memory. biorxiv.org/content/10.110…
Happy to share our work in @NatureMicrobiol. Gamma-Mobile-Trio systems are mobile elements rich in bacterial defensive and offensive tools. If you're interested in #Antiphage #T6SS #Vibrio #MGE then this is for you. 🧵1/15 rdcu.be/dXMwQ nature.com/articles/s4156…
"You can check out any time you like, but you can never leave" Hotel California for #phage on TWiV 1151 #podcast microbe.tv/twiv/twiv-1151/ @profvrr @theMaxwellLab @pramalpatel
Preprint alert 🚨! I present you the second and final manuscript on the BASEL phages! 36 new deeply characterized phages from viral groups that were so far mostly terra incognita - and all infect the E. coli K12 lab strain with easy tricks. 1/12 tinyurl.com/3xdt65f5
A nice little highlight here in @NatureRevMicro by @cazares_adr and team on our work (+ from the Dechesne lab) rediscovering plasmid-dependent phages! A hundred or so are known (most isolated in the last few years!) and we've only scratched the surface 👀 nature.com/articles/s4157…
An anti-CRISPR that (quite literally) deconstructs #CRISPR – was a pleasure spotlighting this latest discovery from the Davidson Lab in @MolecularCell, with @PeterFineran. Speculation included! authors.elsevier.com/a/1jjHE3vVUPRm…
Latest from the lab! PICI and prophage-encoded Tai proteins protect cells by blocking phage tail assembly. Prophages counter with a mechanism allowing tail formation after induction. Defence and counter-defence genes are organised for expression. nature.com/articles/s4146…
nature.com/articles/s4146… Control of lysogeny and antiphage defense by a prophage-encoded kinase-phosphatase module
🚨 It's out!: There's a new toxin in town.. Chelona Toxin—a promising alternative to diphtheria toxin for targeted drug delivery that bypasses pre-existing antibodies, boosting efficacy and safety for next-gen therapeutics. 🧬 @EmboMolMed embopress.org/doi/full/10.10…
Out today in @Nature! I am thrilled to share our work on the PARIS immune system in its final published form. Huge thanks to my mentor, Kevin Corbett @_KevinCorbett, and my teammates. See the thread below in comment section for a quick summary! nature.com/articles/s4158…
Thrilled to share the final version of my postdoc project, out today in @Nature! We investigated the Bil system – a ubiquitin-like antiphage defense system – and discovered a new defense mechanism! More info in the thread below 👇 nature.com/articles/s4158…
Nature research paper: An anti-CRISPR that pulls apart a CRISPR–Cas complex go.nature.com/3VJPeQm
Check out our new paper at Nature rdcu.be/dMEcv We found an anti-CRISPR that pulls apart a type I-F CRISPR-Cas complex by binding to the Cas7 subunits and extracting them one at a time. Big Congrats!! to my pdf Chantel Trost who did most of the work.
Check out the latest story from the Sternberg group: phages coopted transposon-encoded nucleases (TnpB) and repurposed them for regulation of host genes! nature.com/articles/s4158… Thrilled to see this work in print, & a huge thanks to my amazing co-authors!!
A picture is worth 1536 plaque assays. While we used a robot, we also tried a dirt-cheap 3D-printed alternative which works wonders at 384-density. I really believe this pre-print has the potentially to be the largest impact I will make on my field. biorxiv.org/content/10.110…
Thrilled to see this one out! It's been so much fun to go over so many great papers from the last years 🙏🏼
Thrilled to see this one out! It's been so much fun to go over so many great papers from the last years 🙏🏼
Excited to share my preprint from @aaronwhiteley lab showing how a bacterial NLR-related protein detects phages through the host chaperone DnaJ! This is one of the few ssRNA phage defense systems identified, and we found an interesting detection mechanism biorxiv.org/content/10.110…
Our paper on the mechanism of phage sensing and restriction by toxin-antitoxin-chaperone (TAC) systems is out in @cellhostmicrobe! We study two antiphage TACs: HigBAC and CmdTAC. @gem__atkinson @HenrikStrahl @AHarms485 @medfak_LU @lunduniversity cell.com/cell-host-micr…
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207 Followers 469 Following Molecular biology in phage-bacteria interactions | Postdoc in @KotaroKiga ‘s group in the NIID, Japan | Alumni of the @JoergLab in @Helmholtz_HIRI
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738 Followers 1K Following 1st year PhD student of #Microbiology at @ag_boettcher at @Univienna. Passionate about #phages, embroidery and painfully bad puns!
Yash acharya @yash_amr
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Claudia Villicaña Ph... @KlausVillicana
183 Followers 319 Following Researcher in molecular biology at CIAD Culiacán #IxM_CONAHCYT #BIMOGENLab, Communicating science!!!
Cayla Burk @caylabacter
40 Followers 96 Following PhD student in the Department of Molecular Genetics at @UofT • @UofG alum • Sourdough and sour beer enthusiast
Matthias D. Koch @MatthiasDKoch1
421 Followers 696 Following Optically trapped superposition of biophysics and molecular biology, infused with cycling and cooking, to study the mechanical host-microbe interaction (he/him)
Women In Bacteriophag... @Women_In_phage
2K Followers 687 Following A haven for all female bacteriophage researchers across the globe 🌏 👩🔬 #bacteriophage #Phage_Therapy #WomenInSTEM #WomenInPhage💫✉️[email protected]
David Gerlach @davidgerlach9
155 Followers 598 Following Postdoc in bacterial systems biology in the Heilbronner lab, LMU. Previously Peschel lab and Brochado lab.
Naveen @__Naveen____
60 Followers 714 Following Graduate student at UCC II Teagasc. Alum @Tzuchi_Univ & @SRM_Univ • Enjoys working with bacteriophages and playing around with diagnostic kits :)
Thomas Todeschini @TCTodeschini
182 Followers 416 Following Postdoc in the @ESontheimerLab at @RTI_UMassChan. PhD graduate from @NobregaFL lab.
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45 Followers 199 Following He/him. Graduate Student, Maxwell Lab, University of Toronto. Phage-bacteria interactions in Pseudomonas aeruginosa.
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59 Followers 114 Following Doctoral candidate in Microbiology @lifescimunich @LMU_Muenchen
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555 Followers 2K Following Systems Biology PhD Student @Harvard, Labs of @MichaelMDesai & @baym | @TrinCollCam Alum | Evolution & Microbes
Microbiology @X_Microbiology
2K Followers 4K Following #Bacteria #Virus #Parasite #Fungi #Microbiological_News_Story #Research #Comment #Communcation
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11 Followers 50 Following 🇨🇦🇸🇰 PhD student at ETH Zürich. Phage engineer. Street art aficionado. Writer and bookworm.
Véronique @VeroniqueO5
458 Followers 391 Following PhD student at @Claessenlab and @BriegelAriane interested in bacteriophages and cell wall-deficient cells.
Dr. Natalia Hubbs @NataliaHubbs
191 Followers 291 Following Viruses and bacteria=Life. Associate Professor of Biology at Aquinas College. All views are my own.
Vaibhav Rokade @Vaibhav19051991
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2K Followers 5K Following 🇲🇽 Biological engineer living in 🇪🇨. Learning from biology ( #SynBio, #Evolution, #Biochemistry, #Biodiversity...)
BTCC @BTCCexchange
356K Followers 593 Following Longest-serving crypto exchange since 2011 | Global Brand Ambassador: @jarenjacksonjr | 🔥 #BTCCxJJJ 🛡️ #ProvenDefense Posts are not directed towards UK users
Tara Bartolec @TaraBartolec
455 Followers 837 Following EIPOD-LinC postdoc fellow in the Savitski and Typas labs at EMBL, Heidelberg. #XLMS #proteomics #phage Mastodon: @[email protected] 🇦🇺🦠🧑🔬
Jose Luis Balcazar @balcjos
3K Followers 2K Following Senior Researcher at @IcraWater💧 Focus on #microbiology, #AMR, #OneHealth, #biofilms, #phages, #plastisphere, #metagenomics, and #bioinformatics
Dhruti Patel @p_dhruti09
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kruthi rao @_kruthirao_
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Motaher Hossain @MotaherH2020
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Lupita Valencia @Lupis_ValenCIA
173 Followers 504 Following Postdoctoral researcher at Texas A&M University🦠🧬 Microbiologist Phage lover Mtb-girl
Jolene Ramsey @jrrmicro
870 Followers 294 Following #latina #scientist @jrrmicrolab PI | phavorite viruses are #phage | loves the outdoors | she/her/ella
ImmunoSketch @ImmunoSketch
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The Phage @The_Phage_xyz
549 Followers 126 Following Science 🧪 website | phage-based hub | Friend of the good virus
Chantel N. Trost @Chantel_N_Trost
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717 Followers 798 Following 🧪 Bacteria, Phages & Genomics 💻 Synthetic Biology Group @institutpasteur 👩🔬 PhD @GVAfisabio @i2sysbio
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Jess Neubauer @Biolojess
738 Followers 1K Following 1st year PhD student of #Microbiology at @ag_boettcher at @Univienna. Passionate about #phages, embroidery and painfully bad puns!
Sternberg Lab @SternbergLab
1K Followers 17 Following News from the Sternberg lab at Columbia Univ., HHMI. Posts are from lab members and not Samuel Sternberg unless signed SHS. Posts represent personal views only.
Sam Sternberg @shsternberg
6K Followers 646 Following Associate Professor at Columbia University / HHMI Investigator / CRISPR aficionado / Protein–RNA biochemist / Co-author of "A Crack In Creation"
Matthias Fischer @the_fischer_lab
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Matthias D. Koch @MatthiasDKoch1
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Milan Gerovac @Milan_Gerovac
484 Followers 1K Following I farm very small life, cook in tiny volumes, and taste by fancy figures junior research group 'Complexes in Phage-infected Cells' @Helmholtz_HZI
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Nature Communications @NatureComms
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RevathyKrishnamurthi @Revathykri
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