Yuchun Guo @yguo2k
Computational Biology Scientist in Biotech, Greater Boston. interested in #MachineLearning, #GeneRegulation, #RNA, anti-sense oligo linkedin.com/in/yuchun-guo/ Cambridge, MA Joined April 2015-
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Today we’re releasing an alpha version of RibonanzaNet2. Rnet2 is a 100M-parameter foundation model for #RNA structure, trained on chemical mapping profiles for 30M RNAs with complex structure. kaggle.com/c/stanford-rna… (1/N)
Are RNA 3D models accurate enough to be biologically useful? #CASP16 experimentalists say: not so much. doi.org/10.1101/2025.0… Thanks for leading this paper @RachaelKretsch @AKryshtafovych! 1/2
Our CFO Kelly Gold and Co-Founders Richard Young & Leonard Zon spoke with @ZachinBoston about our work in #regRNA biology to upregulate #GeneExpression and potentially correct protein deficiencies underlying many genetic diseases. More in this @MIT article:bit.ly/4iBnzL2
Announcing the new Pseudogenes track for hg38! The composite track contains pseudogene predictions and their corresponding parent genes, as identified by PseudoPipe. This release includes the Pseudogene Parents and Pseudogenes tracks. Learn more at genome.ucsc.edu/goldenPath/new….
I'm honored to be inducted as a fellow into the American Institute for Medical and Biological Engineering @aimbe. Had a great visit to Capitol Hill and advocated for biomedical engineering research. @NU_BMG_SQE @NUFeinbergMed
#RNA structure prediction remains unsolved -- nice tech feature incl #deeplearning and #CASP16 in @Nature nature.com/articles/d4158…
Applying for a Bioinformatics position? Your CV competes with hundreds of others. Here’s how to stand out, based on my hiring experience: 🧵👇
Diverse Database and Machine Learning Model to narrow the generalization gap in RNA structure prediction bioRxiv biorxiv.org/cgi/content/sh…
Existing methods normalize epigenetic features independently and distort relationships among the features. JMnorm jointly normalizes multiple features, enables data sharing and preserves the relationships. It works even with only two features, e.g. ATAC and H3K27ac.
Existing methods normalize epigenetic features independently and distort relationships among the features. JMnorm jointly normalizes multiple features, enables data sharing and preserves the relationships. It works even with only two features, e.g. ATAC and H3K27ac.
Nature research paper: Cell type directed design of synthetic enhancers go.nature.com/3RkatGn
#ICYMI: CAMP4’s scientific founders recently shared their insights on #regRNAs, the foundation of our novel science. 🏔️Watch the highlights to learn about the potential of our game-changing approach in #genetic diseases: ow.ly/Vm2c50PIKKu
We are thrilled to share our manuscript ‘An RNA foundation model enables discovery of disease mechanisms and candidate therapeutics’ as a preprint! 🧵 biorxiv.org/content/10.110…
You can now give a try to RNArtist for MacOS/Linux (Windows next week). This project is under active development: it is not perfect and many exciting features will come soon. All details here: github.com/fjossinet/RNAr… #bioinformatics #RNA #visualization #java #javafx #kotlin
We’ve teamed up with @kaggle and the global #deeplearning community to accelerate progress in #RNA structure prediction. Check out the new #Ribonanza challenge: kaggle.com/c/stanford-rib… 1/7
😲 Time to revise textbooks 🤔 Title: "Transcription factors interact with RNA to regulate genes" "at least half of TFs also bind RNA, doing so through a previously unrecognized domain" cell.com/molecular-cell…
"Sensitive remote homology search by local alignment of small positional embeddings from protein language models" ESM2 embeddings used " as input to the highly optimized Foldseek, HMMER3, and HH-suite search algorithms" biorxiv.org/content/10.110…
Delighted to share a short review article published in @ScienceAdvances!! Enhancer dynamics: Unraveling the mechanism of transcriptional bursting. science.org/doi/10.1126/sc…
Read this from @WhiteheadInst on findings from CAMP4 co-founder @youngricka’s lab, published in @MolecularCell, showing that RNA binds to transcription factors to regulate #geneexpression, providing biological validation to CAMP4’s approach. #RNADay
Read this from @WhiteheadInst on findings from CAMP4 co-founder @youngricka’s lab, published in @MolecularCell, showing that RNA binds to transcription factors to regulate #geneexpression, providing biological validation to CAMP4’s approach. #RNADay
All talks from the main #RECOMB2023 meeting are now available at: youtube.com/playlist?list=… Also: Day 1: youtube.com/playlist?list=… Day 2: youtube.com/playlist?list=… Day 3: youtube.com/playlist?list=… Day 4: youtube.com/playlist?list=…
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Pennsylvania NY NJ Bi... @PNBionetwork
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bea carreon @bea_carre0n
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362 Followers 278 Following The CEGR is composed of ten laboratories with over 70 students and staff. We aim to provide a conducive learning environment for making cutting edge discoveries
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178 Followers 220 Following Science enthusiast, Bioinformatics and Genomics Ph.D. student @ Penn State.
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27 Followers 394 Following PhD in bioinformatics. Class of 2021 from Sichuan University. https://t.co/rzbygqrkTj
Yaping Liu @yapingliu
426 Followers 594 Following Assistant Professor in epigenomics and liquid biopsy, Northwestern University-Feinberg School of Medicine. Husband and a father of two kids.
Robinthebear @softbear_
472 Followers 4K Following Cancer genomics by day, drug discovery by night. Let’s integrate those datasets and solve cancer. he/him
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26K Followers 3K Following Federally funded academic research is the innovation engine of the US economy. Reform is welcome. Destruction will have long term consequences.
Models, Inference & A... @MIA_at_Broad
428 Followers 253 Following MIA supports learning and collaboration across the interface of biology and medicine with mathematics, statistics, machine learning, and computer science.
Sergey Ovchinnikov @sokrypton
16K Followers 4K Following Scientist, Assistant Professor @MITBiology, #FirstGen, ProteinBERTologist, 🇺🇦 No Human is illegal. Moving to: https://t.co/sow6IRD3jj
Divyanshi Srivastava @divyanshi91
178 Followers 220 Following Science enthusiast, Bioinformatics and Genomics Ph.D. student @ Penn State.
ICML-Compbio-Workshop @icml_compbio
905 Followers 18 Following ICML Workshop on Computational Biology - official website https://t.co/eWk4V3vx2A
BevilacquaLab @phil_bevilacqua
3K Followers 2K Following RNA chemistry and biology: Ribozyme mechanism and function; RNA structure and gene regulation in vivo; early Earth and RNA. (he, him)
Martin Smith @martinalexsmith
4K Followers 1K Following Genomics technocrat, Bioinformatics, RNA & Bash-Fu 🥷; Director @ramacgenomics ; Associate Prof. @UNSWBABS ; Member of @UNSWRNA
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11K Followers 350 Following MLing biomolecules en route to structural systems biology. Asst Prof of Systems Biology and CS @Columbia. Prev. @Harvard SysBio; @Stanford Genetics, Stats.
Charles Danko @charlesdanko
2K Followers 761 Following I study how genome sequence controls gene expression at Cornell.
Das Lab @RDasLab
2K Followers 110 Following Our lab seeks an agile and predictive understanding of how RNAs structurally code for information processing and replication in living systems.
RockyNPS @RockyNPS
82K Followers 85 Following The official twitter page of Rocky Mountain National Park. Updates and important information.
MeyerLab @MeyerLabDuke
2K Followers 158 Following Assistant Professor @DukeU studying RNA biology and the epitranscriptome.
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Open Targets @OpenTargets
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RNA @RNAJournal
7K Followers 535 Following The official journal of the RNA Society. Featuring cutting edge research in RNA Biology, biochemistry, genetics, cell biology, structural biology and genomics
Chaolin Zhang @chaolinzhang
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CAMP4 Therapeutics @camp4tx
500 Followers 37 Following We are pioneering a new approach to upregulate genes by targeting regulatory RNA using programmable oligonucleotide therapeutics.
loop_enhancer @EnhancerLoop
2K Followers 236 Following Enhancer papers manually picked by @IvKrivega. Views are my own. #chromatin #enhancer #synteticbiology #geneediting
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Transcription Factors @AllAboutTFs
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818 Followers 89 Following The CSB PhD Program integrates MIT's world-class research and educational opportunities in biology, engineering, and computer science.
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Scientific American @sciam
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