YouleLab @LabYoule

Youle Lab members. Mitophagy, mitochondrial quality control and autophagy lab. Molecular mechanisms underlying early onset Parkinson's disease. Bethesda,MD Joined June 2020

Tweets

51
Followers

1K
Following

121
Likes

97

YouleLab @LabYoule

2 years ago

Exciting mitochondria news! Check out the new preprint by @PoratShliomLab group, led by @SunWooSophieKa1 with assistance from @RoryCunningham, Colin Miller, Conny Cultraro. Discover how they studied the functional diversity of hepatic mitochondria using Intravital Microscopy:

Natalie Porat-Shliom @PoratShliomLab

2 years ago

6 21 77 35K 7

0 3 8 2K 0

YouleLab @LabYoule

3 years ago

Next Thursday February 9th, Dr. Richard Youle (@youle_rj ) will be talking about the work that has been done in our lab on #mitochondria quality control at the Aging Institute-University of Pittsburgh @AgingPitt (zoom link💻/location in the image from the original tweet)

Aging Institute at the University of Pittsburgh @AgingPitt

3 years ago

0 6 17 5K 0

Download Image

0 1 13 2K 0

YouleLab @LabYoule

3 years ago

@slavov_n Pink1 is another example of a protein constitutively translated only to be degraded. Upon import impairment of an individual mitochondrion Pink1 proteolysis is prevented allowing it to accumulate on that mitochondrion to recruit Parkin and initiate mitophagy.

0 2 15 0 1

Eunice Domínguez-Martín, PhD @Lluniz

4 years ago

Found a spooky #bacteria #ghost transformation in the Lab!!! @LabYoule #GlowintheDark #halloween2021 #GFP #ScienceIsFun 👻🎃💀

0 2 6 0 0

Download Image

Journal of Cell Biology @JCellBiol

4 years ago

The VPS13 proteins are thought to mediate #lipid transport between organelles & are linked to distinct neurological disorders. Baldwin, @LabYoule et al. find that, in addition to mitochondrial morphology, VPS13D is essential for peroxisome biogenesis. bit.ly/3sMSxpq

1 24 79 0 7

Download Image

YouleLab @LabYoule

4 years ago

Very happy to share with you the recent news that Richard Youle was elected as a member of the American Academy of Arts and Sciences! @americanacad Congratulations @youle_rj !🥳

American Academy of Arts & Sciences @americanacad

4 years ago

Very happy to share with you the recent news that Richard Youle was elected as a member of the American Academy of Arts and Sciences! @americanacad Congratulations @youle_rj !🥳

10 46 289 0 8

Download Image

15 3 78 0 0

mito911 @mito911_

4 years ago

📌Talk by Richard Youle @youle_rj @LabYoule 🗓️12th May 2021 - 1pm EDT REGISTER HERE: zoom.us/webinar/regist…

1 5 16 0 1

Download Image

YouleLab @LabYoule

5 years ago

Want to understand how deficiencies on the ubiquitin-mediated protein quality control systems are associated to neurodegeneration? Read this insightful review by François Le Guerroué and @youle_rj! Still 6 days for free! rdcu.be/cfHZu #PD #Alzheimers #PD #ALS #PTD

0 16 33 0 3

Download Image

Journal of Cell Biology @JCellBiol

5 years ago

Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes. A novel pooled screening approach from Gil Kanfer (@gil_kanfer) Richard Youle (@youle_rj) and colleagues from @LabYoule @JLS_Lab: bit.ly/3bURzCz #autophagy #mitochondria #AI

0 5 13 0 2

Download Image

YouleLab @LabYoule

5 years ago

Thrilled to share with you our latest publication led by @gil_kanfer. Here we describe a novel image-based method to perform #CRISPRi screening to detect changes in subcellular phenotypes using high-content imaging and #MachineLearning. #autophagy #mitochondria #lysosomes #AI

Rockefeller U. Press @RockUPress

5 years ago

0 15 36 0 8

Download Video

2 25 61 0 3

YouleLab @LabYoule

5 years ago

Don't forget to follow Shireen Sarraf's presentation tomorrow: Loss of TAX1BP1-directed autophagy results in protein aggregate accumulation in the brain. 10:30am EST @WAutophagy 1st Annual Symposium #autophagy #neurodegeneration @LabYoule

Women in Autophagy @WAutophagy

5 years ago

0 9 20 0 0

Download Image

0 2 7 0 0

YouleLab @LabYoule

5 years ago

We invite you to watch @Jobby1kanobi presenting the work he developed @LabYoule on how the #autophagy receptor NDP52 and TBK1 mediate ULK1 recruitment and activation during #mitophagy @AIM_autophagy Early Career Investigator Series autophagy.center/super/videos/8…

0 5 15 0 0

YouleLab @LabYoule

5 years ago

It's publication time at the lab! We are excited to share @asdfTARAghjkl report in collab with M. Lazaraou´s lab describing that ATG16L1 is required for V-ATPase-mediated LC3B lipidation on single membranes upon the activation of the innate #immune receptor STING #autophagy

Journal of Cell Biology @JCellBiol

5 years ago

1 16 46 0 3

Download Image

1 5 31 0 0

YouleLab @LabYoule

5 years ago

Protein aggregation is a pathological hallmark of #neurodegeneration, so we are very proud to announce our latest publication led by Shireen Sarraf in which she described the role of the #autophagy receptor #TAX1BP1 on the clearance of protein aggregates #ALS #HD @NINDSnews

Molecular Cell @MolecularCell

5 years ago

0 6 25 0 1

1 13 43 0 1

TweetALS @TweetALSMND

5 years ago

Looking to leverage existing systems to clear out protein aggregates to tackle neurodegenerative diseases such as #ALS #MND? @MolecularCell Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain bit.ly/32TWbUq @LabYoule

0 6 14 0 1

Download Image

YouleLab @LabYoule

5 years ago

Happy to share with you this interesting review on the relationship between mitochondria quality control mechanismsb and immunity from @atmoehlman @youle_rj @LabYoule annualreviews.org/doi/10.1146/an…

0 21 60 0 5

The Nobel Prize @NobelPrize

5 years ago

BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”