Peter Simmonds @Simmonds_Lab

Peter Simmonds runs a research group in University of Oxford. Very interested in the broader evolution of viruses and constraints under which they are placed. ndm.ox.ac.uk/principal-inve… Oxford, England Joined June 2017

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Peter Simmonds @Simmonds_Lab

a year ago

Here is my re-visiting of the C->U hypermutation phenomenon in SARS-CoV-2 genome 4 years from the start of the COVID pandemic: tinyurl.com/mw3ezp6c A trajectory of loss of C's / gain of U's, but weak 5' context effect and RNA structure dependence on edited sites. APOBEC 3A??

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Derek Gatherer @DerekGatherer

2 years ago

Before #COVID19, when was the last #coronavirus #pandemic? Some have argued for 1889-1892 for the zoonosis of human #OC43 from bovine coronavirus, but in our new paper: journals.plos.org/plosone/articl…, we suggest 1899-1900, based on a review and replication of existing molecular data.

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Jeremy Ratcliff @jeremydratcliff

2 years ago

Have you ever wondered how nucleic acid editing pathways (APOBEC, ADAR, and epitranscriptomics) might impact the adaptation of zoonotic viruses to humans? Of course you have! Lucky for you, we have a new review in COVIRO considering just that issue: authors.elsevier.com/c/1gtX36hO9tXx…

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Virus infections and immunity @awesome_viruses

2 years ago

The largest study to date on the viruses residing within our tissues Unmasking the tissue-resident eukaryotic DNA virome in humans academic.oup.com/nar/advance-ar…

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Tanya Golubchik @tanyagolubchik

4 years ago

Come and work with some fantastic people (Oxford/UCL) on using genomics to improve safety of transfusion and transplantation: jobs.ac.uk/job/CKU178/pro… jobs.ac.uk/job/CKV942/pos… Fully funded Oxford PhDs: ndm.ox.ac.uk/study/dphil-th… Fully funded UCL PhD: jobs.ac.uk/job/CKJ558/phd…

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Heli Harvala @HarvalaHeli

4 years ago

Fantastic thread - we report here a total of 139 EV-D68 cases from Europe, most of them in September and numbers are likely to increase. A timely reminder that you will only find what you are looking for!

Helen Branswell 🇨🇦 @HelenBranswell

4 years ago

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Heli Harvala @HarvalaHeli

4 years ago

Are you ready and looking for it! Did you know EV-D68 is back? Thankful for the great collaboration! @ENPEN_ESCV @KimBenschop @TheaKFischer @Simmonds_Lab @ESCVirology @Eurosurveillanc eurosurveillance.org/content/10.280…

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Peter Simmonds @Simmonds_Lab

4 years ago

Disaster - are we going back to square 1? Despite the vaccine coverage

Aris Katzourakis @ArisKatzourakis

4 years ago

Disaster - are we going back to square 1? Despite the vaccine coverage

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Peter Simmonds @Simmonds_Lab

4 years ago

Very nice article comprehensively reviewing aspects of compositional bias in RNA viruses & interrelationships with still poorly characterised cellular mechanisms responding to RNA sequence motifs - ZAP, APOBECs, ADAR & many more, and selection biases from effects on translation

Elly.Gaunt_lab 💙 @GauntLab

4 years ago

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Mattia Ficarelli @MattiaFicarelli

4 years ago

Our review of the ZAP antiviral pathway and how it specifically targets viruses is out in @AnnualReviews. Thank you to @stuartjdneil & @Swanson_Chad. annualreviews.org/doi/abs/10.114…

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Heli Harvala @HarvalaHeli

4 years ago

See you there!

ESCV Virology @ESCVirology

4 years ago

See you there!

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Peter Simmonds @Simmonds_Lab

4 years ago

Very experimental but also very surprising, here is some evidence for excess C->U changes in a range of mammalian RNA viruses, potentially related to the much discussed phenomenon in SARS-CoV-2: doi.org/10.1371/journa… Consequences for virus evolution: interesting.....