Yang Yang @YYang_Lab
Assistant Professor at Iowa State University | Coronavirus | RNP complexes | cryo-EM yyanglab.org Ames, IA Joined September 2019-
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This is super exciting!
Another update on the mysterious OLE #ncRNA from bacteria. In @jbiolchem we report a third essential protein partner called OapC, which alters RNA folding to form a k-turn. We still think OLE is a #ribozyme relic from the #RNAWorld. pubmed.ncbi.nlm.nih.gov/36336078/
A new Science study reveals structures of an RNA proofreader, viral nsp14 exoribonuclease, in coronaviruses that is crucial to maintaining the integrity of their unusually large RNA genomes. It provides insight that could guide antiviral development. fcld.ly/ke02gic
A new study reveals structures of an RNA proofreader, viral nsp14 exoribonuclease, in coronaviruses that is crucial to maintaining the integrity of their unusually large RNA genomes. It provides insight that could guide antiviral development. fcld.ly/t37hiz2
Structural snapshots of EcmrR-dependent transcription provide insight into the recognition of suboptimally structured promoters by the MerR family TFs. @YangYan79739357 go.nature.com/33FRMo2
Structural snapshots of EcmrR-dependent transcription provide insight into the recognition of suboptimally structured promoters by the MerR family TFs. @YangYan79739357 go.nature.com/33FRMo2
Check out the #cryoEM structures of the intact CueR-dependent transcription activation complexes from Shi et al. at @UMNews dlvr.it/RzRfnl
The MerR family of transcriptional regulators activate bacterial transcription through promoter modeling. This process is now visualized for two regulators in our @NatureComms and @iScience_CP papers: nature.com/articles/s4146… cell.com/iscience/fullt…
The biochemical function of OLE RNA is still unknown, but about 10% of this large #noncoding #RNA structure is now modeled at atomic resolution with one of its protein partners. OLE provides bacterial resistance to cold, alcohols, and Mg2+. See: pnas.org/content/118/9/… @PNASNews

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