Kaiwen Chen @_kaiwenchen
Assistant Professor @NUSMedicine. Department of Microbiology and Immunology. Cell death. Innate immunity. Inflammation. nus.edu.sg/lsi/principal-… Singapore Joined August 2018-
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Kaiwen Chen retweeted
Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3) shorturl.at/8lWxW
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Kaiwen Chen retweeted
Fantastic work by @inflammasomelab showing in vivo the importance of regulating caspase-1 activity in inflammatory conditions! Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases biorxiv.org/content/10.110…
Kaiwen Chen retweeted
🔥 Open postdoc position in human inflammation-driven control of infection! Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! Please RT (1/5)
Kaiwen Chen retweeted
Excited to share our latest paper: TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation in @emboreports embopress.org/doi/full/10.10… #FrazerInstitute @UQMedicine @TRI_info
Kaiwen Chen retweeted
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.@FabiAlexFischer science.org/doi/10.1126/sc…
Kaiwen Chen retweeted
We are excited to share a new paper from the lab - led by first author and @cwrumstp @CWRUSOM student Meghan O'Keefe. 1/n Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP: Cell Reports cell.com/cell-reports/f…
Kaiwen Chen retweeted
We have a fully funded PhD scholarship for Aug 2025 intake. If you are interested in joining our research group, please check the admission requirement on the website and contact us. ntu.edu.sg/education/grad…
Thrilled to start 2025 with our latest findings! @fallfelfallen Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive cell.com/cell-reports/f…
Kaiwen Chen retweeted
In this study, Tye et al show how RIPK3-caspase-8 signaling induces inflammation to drive MAFLD, while MLKL noncanonically regulates lipid accumulation and metabolism to drive obesity and MAFLD. @_KateLawlor @CiiiD_Hudson @Hudson_Research @WEHI_research life-science-alliance.org/content/8/1/e2…
Kaiwen Chen retweeted
Hot off the press! 🔥 In our latest @NatureComms paper, we used in vivo imaging to track EV formation in the bone marrow microenvironment. We found that circulating EVs correlates with tissue damage caused by leukemias like AML! @WEHI_research @latrobe @AusCellDeathSoc
Hot off the press! 🔥 In our latest @NatureComms paper, we used in vivo imaging to track EV formation in the bone marrow microenvironment. We found that circulating EVs correlates with tissue damage caused by leukemias like AML! @WEHI_research @latrobe @AusCellDeathSoc
Kaiwen Chen retweeted
🚨PhD position opening in our lab at the Department of Immunobiology (DIB) in Lausanne! We are searching for a curious and motivated PhD student to study #innateimmunity, #inflammasomes or #NINJ1-induced cell death. For details: tinyurl.com/PBDIB Please RT and/or apply!
Kaiwen Chen retweeted
PhD/DPhil applications at the @KirOxford are now open for 2025! Check out all the projects; and then apply to our project 😀! Advertised with @AGerardLab to study macrophage signalling in tumours.
Kaiwen Chen retweeted
Many cytosolic proteins are released by cell death. Why do some become autoantigens? In a team work led by Esther Jones and @LD53073604, we explore the story of a common autoantigen, TRIM21
Many cytosolic proteins are released by cell death. Why do some become autoantigens? In a team work led by Esther Jones and @LD53073604, we explore the story of a common autoantigen, TRIM21
Kaiwen Chen retweeted
Excited to share our new review @NatRevImmunol on #inflammasome components as new therapeutic targets in inflammatory disease 🔥💊 Led by the one and only @inflammasomelab full text here: rdcu.be/dTqxt
A number of new studies on gasdermin were published recently. @broz_lab and I put together a review to summarise and discuss our current understanding of gasdermins during cell death and inflammation. nature.com/articles/s4155…
Kaiwen Chen retweeted
Interested in Caspase and LPS signalling? Looking for a multidisciplinary position with a bit of immunology, biochemistry and host-pathogen interactions? Look no further! Our lab is recruiting a second PDRA funded by @BBSRC. See details below
Interested in Caspase and LPS signalling? Looking for a multidisciplinary position with a bit of immunology, biochemistry and host-pathogen interactions? Look no further! Our lab is recruiting a second PDRA funded by @BBSRC. See details below
Kaiwen Chen retweeted
Really excited to share a short tweetorial of some of my work as a grad student in the @BrodskyIgor lab @pennvet, now in press at @ScienceAdvances! 🧵👇science.org/doi/10.1126/sc…
Kaiwen Chen retweeted
📢Latest @NatureCellBio:"Full-length GSDME mediates #pyroptosis independent from cleavage" by Zhou, Jiang, Dai, Chen, Wu & co. #celldeath nature.com/articles/s4155…
The first paper from the Chen lab is out! Congrats @seejie_yow on dissecting the cell type-specific requirements for Yersinia-induced pyroptosis in neutrophils and macrophages! rdcu.be/dMNeZ
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