Anthony Rullo: chemically modulating proximity @LabRullo
Covalent and multivalent - proximity inducing strategies for basic and translational chemical biology rullolab.com Joined June 2019-
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Anthony Rullo: chemically modulating proximity retweeted
Zongertinib: A Covalent, Brain-Penetrant HER2-Selective TKI for HER2-Mutant nSCLC Gets FDA Approval | drughunters.com/47Ho98f Zongertinib (Hernexeos®, BI 1810631) is a covalent, HER2-selective TKI approved by the FDA in August 2025 for patients with unresectable or metastatic…
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Anthony Rullo: chemically modulating proximity retweeted
Small-Molecule Ligands Targeting Lysosome-Shuttling Receptors and the Emerging Landscape of Lysosome-Targeting Chimeras | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…
Anthony Rullo: chemically modulating proximity retweeted
Really nice piece of chemistry. pubs.acs.org/doi/10.1021/ja…
Anthony Rullo: chemically modulating proximity retweeted
TWeeP (This Week's Paper): PROTACs and other chemical dimerizers are based on non-inhibitory ligands which are hard to come by. The Kodadek lab presents a clever assay for mining such binders using one bead–one compound libraries. Now out in @J_A_C_S! pubs.acs.org/doi/10.1021/ja…
Beautiful perspective on microbial carbohydrate chemistry and biochemical applications from the Lupoli lab! pubs.acs.org/doi/10.1021/ac…
Anthony Rullo: chemically modulating proximity retweeted
What if treating disease meant stabilizing biology, not blocking it? We explore that idea in @ScienceMagazine with LOCKTAC molecular glues, a new class of molecules that stabilize natural interactions to either boost or block biology. science.org/doi/10.1126/sc… #mycompnay
Anthony Rullo: chemically modulating proximity retweeted
Distinct Electric Fields Enable Common Catalytic Function in Structurally Diverse Enzymes | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…
Anthony Rullo: chemically modulating proximity retweeted
Entropy-Regulated Selective Synthesis of Cyclic Polymers and Polycatenanes by Lewis Pair Polymerization | Journal of the American Chemical Society @ColoradoStateU pubs.acs.org/doi/10.1021/ja…
Anthony Rullo: chemically modulating proximity retweeted
Intrastrand Peptide Staples That Promote β-Sheet Folding, Self-Assembly, and Amyloid Seeding | Journal of the American Chemical Society @NotreDame pubs.acs.org/doi/10.1021/ja…
Anthony Rullo: chemically modulating proximity retweeted
Ray Deshaies has a new piece in Nature Reviews Drug Discovery on how multispecific drugs are reshaping pharmacology. During his time at @Amgen, Ray challenged us to rethink what molecules could do, especially with induced proximity. #MyCompany nature.com/articles/s4157…
Anthony Rullo: chemically modulating proximity retweeted
How multispecific molecules are transforming pharmacotherapy nature.com/articles/s4157… This new article by Raymond Deshaies discusses how a wave of drugs designed to engage two or more entities are overcoming development barriers such as toxicity, rapid clearance and redundancy
Anthony Rullo: chemically modulating proximity retweeted
Cool @biorxivpreprint from @Michael_A_Erb on Rewiring DNA repair with PARP-based chemical inducers of proximity | bioRxiv biorxiv.org/content/10.110…
incredibly useful and elegant tumor imaging technology out of the Perrin lab!
incredibly useful and elegant tumor imaging technology out of the Perrin lab!
Anthony Rullo: chemically modulating proximity retweeted
Elucidating Electric Field-Induced Rate Promotion of Brønsted Acid-Catalyzed Alcohol Dehydration | Journal of the American Chemical Society @ChemistryMIT @MIT @yogi_chem @DincaGroup @yuriy_roman @MITChemE pubs.acs.org/doi/10.1021/ja…
Anthony Rullo: chemically modulating proximity retweeted
Join us for our July #CDCRSeminar with speaker: Prof. Jakob Magolan from the department of Biochemistry & Biomedical Sciences! 📅 Thursday, July 31, 2025 at 4pm 🕓 MDCL 3020 or Zoom 🔗 cdcr.mcmaster.ca/events/cdcr-se…
Anthony Rullo: chemically modulating proximity retweeted
A new paper reports a strategy to detect binding to Aβ42 oligomers, which is used to select new binders with improved potency nature.com/articles/s4158…
Anthony Rullo: chemically modulating proximity retweeted
Looking for a great read this weekend? Check out our newest @J_A_C_S pubs.acs.org/doi/10.1021/ja…
Anthony Rullo: chemically modulating proximity retweeted
Cool paper from Monte Rosa on Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition | Science science.org/doi/10.1126/sc…
Anthony Rullo: chemically modulating proximity retweeted
Congrats to @PaschkeAK, @ej_meeus, Florin and our collaborators from the pharmacy institute M. Masota and Prof. Nathalie Grob - Late-Stage Diversification of Peptides and Peptide Drugs through Nitrogen Atom Insertion | @ChemRxiv - go.shr.lc/44mL6Kg
Anthony Rullo: chemically modulating proximity retweeted
[NEW paper!] Proximity-induced O-GlcNAcylation: we showed that a single sugar modification can act as a molecular switch that triggers protein degradation & more!🍬Huge congrats to the OGTAC team!👏Open-Access Article: pubs.acs.org/doi/full/10.10…
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