REVIVED @REVIVED_BCIS2
REVascularisation for Ischaemic VEntricular Dysfunction: a multi-centre prospective randomised control trial. NCT01920048; https://t.co/KrF3aSzPdG revived.LSHTM.ac.uk London, England Joined January 2018-
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In @REVIVED_BCIS2, PCI did not prolong life in patients with ischemic LV dysfunction. But what about symptoms? Our detailed analysis of health status and quality of life out this week in JACC: Heart Failure. jacc.org/doi/10.1016/j.…
Welcome to the @BCIS4Trial X page. This study is funded by the National Institute of Health Research (NIHR) [HTA (NIHR155123]. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care
Mon 8th April (Atlanta) @DrMattRyan 0915 (Rm B213) Does LGE predict segmental recovery in severe LVSD? @REVIVED_BCIS2 analysis 1015 (theater 3) Quality of Life after PCI in severe LVSD: a #WinRatio analysis @REVIVED_BCIS2. @JACCJournals @CTU_LSHTM @markcpetrie20 @jspertus
Rationale and design of the CHIP-BCIS3 randomized controlled trial: LV unloading in high-risk PCI. Just published in @circ CVINT. ➡️ historical challenges of trials in MCS ➡️innovative design and ideal population to deliver a definitive trial bit.ly/4bV3VHu
Thanks to our amazing network of @CHIP_BCIS3 @BCIS_uk investigators, trial management group, oversight committees, funders and all the patients who have volunteered, we are firmly on track to complete the trial and answer important questions about LV unloading in high-risk PCI!
Thanks to our amazing network of @CHIP_BCIS3 @BCIS_uk investigators, trial management group, oversight committees, funders and all the patients who have volunteered, we are firmly on track to complete the trial and answer important questions about LV unloading in high-risk PCI!
Comprehensive overview of ischaemic LV dysfunction 👏🏻 Act fast as free access until 27 January! Most downloaded from The PCR-EAPCI 📗 @PCRonline @divaka_perera @DrMattRyan @REVIVED_BCIS2 @BCIS_uk @CHIP_BCIS3 textbooks.pcronline.com/the-pcr-eapci-…
The REVIVED viability study is now out in print.. Extent of viable myocardium was NOT associated with patient outcomes.. but amount of scar was! @JAMACardio jamanetwork.com/journals/jamac…
The REVIVED viability study is now out in print.. Extent of viable myocardium was NOT associated with patient outcomes.. but amount of scar was! @JAMACardio jamanetwork.com/journals/jamac… https://t.co/SYg9C6LygT
🚨I am delighted to announce that the BCIS intervention training survey is live · Open for all UK Intervention trainees & post CCT fellows. · OOP trainees who have a subspec numbers are also eligible. 🫀Takes 10-15 mins surveymonkey.co.uk/r/bcistraining… @BCIS_uk @TheBJCA @Ryvetsprog
REVIVED-BCIS2 cost/benefit analysis takeaways 💸PCI was not cost-effective vs. OMT alone in patients with CAD + HF 🕰️Intervention conferred greater cost with minimal difference in QALYs @CircOutcomes #Cardiotwitter #AHA23 @KingsCollegeLon Read more 👇 healio.com/news/cardiac-v…
Cost-effectiveness analysis of REVIVED-BCIS2 shows minimal difference in total QALYs (KCCQ & EQ-5D-5L) b/w PCI+OMT🆚OMT alonePCI+OMT🚫cost-effective🆚OMT using estimated mean costs & QALYs in both groups adjusted for clinically relevant predictors ahajournals.org/doi/10.1161/CI… #AHA23
REVIVED cost effectiveness analysis: ➡️ PCI was associated with minimal difference in QALYs + considerable incremental cost ➡️ Probability of PCI being cost effective = 0 ➡️ A strategy of PCI for ILVD is not a justifiable use of healthcare resource #AHA23 ahajournals.org/doi/10.1161/CI…
We are excited to share new data #aha23 #Philly. ➡️ 10:30 Sat Nov 11: @AishSinha1 mechanisms of ischemia in Myocardial Bridges (Samuel Levine Early Career Investigator Awards session) ➡️ 14:25 Fri Nov 10: @hollymorgs health economic analysis by @CHEyork of @REVIVED_BCIS2 data
Getting excited for #AHA23 next week - and looking forward to presenting our @REVIVED_BCIS2 health economic analysis at the QCOR session Friday @ 2.25pm! @CHEyork
This paper in @JAMACardio will change practice/paradigms and hopefully improve the lives of our patients. Thanks to Herculean efforts >10yrs by @REVIVED_BCIS2 group + meticulous work of viability corelabs led by @achir72 and Roxy Senior + funding from @NIHRresearch and @TheBHF.
This paper in @JAMACardio will change practice/paradigms and hopefully improve the lives of our patients. Thanks to Herculean efforts >10yrs by @REVIVED_BCIS2 group + meticulous work of viability corelabs led by @achir72 and Roxy Senior + funding from @NIHRresearch and @TheBHF.
After a median of 3.4 years, there was no difference in the rate of death or heart failure hospitalisation between viability tertiles.
New analysis from @REVIVED_BCIS2. PCI remained ineffective regardless of extent of viability. More importantly measuring "hibernation" is not useful, scar burden is major predictor of events and LV recovery. jamanetwork.com/journals/jamac…
@MinaMadanMD @crfheart @TCTConference @TCTMD @BCIS_uk @BritishCardioSo @mmamas1973 @ShrillaB @Sarah_Moharem @ShaziaTHussain1 @DrNataliaP @SanjogKalra @AlexBastiany @divaka_perera @REVIVED_BCIS2 @divaka_perera delivers the CON: was @REVIVED_BCIS2 “a lot of work, for nothing?” These debates are no Mickey Mouse cartoons, that’s for sure! 😜 @TCTConference @crfheart @TCTMD #TCT2023
Myocardial viability testing does not identify patients with ischemic cardiomyopathy who benefit from PCI. Findings suggest that the extent of dysfunctional yet viable myocardium was not associated with revascularization outcomes. ja.ma/3QFH1vr @REVIVED_BCIS2
Excited to hear from the CI of so many groundbreaking MCS trials like ECLS-SHOCK @thiele_holger and the fabulous UK research network enrolling to @CHIP_BCIS3. Fab agenda too - cases, trial updates, recruitment tips, debates and more, at the amazing Strand Campus @KingsCollegeLon
Excited to hear from the CI of so many groundbreaking MCS trials like ECLS-SHOCK @thiele_holger and the fabulous UK research network enrolling to @CHIP_BCIS3. Fab agenda too - cases, trial updates, recruitment tips, debates and more, at the amazing Strand Campus @KingsCollegeLon
What is the role of revascularisation for ischaemic heart failure after REVIVED? Look today in ICR3 for thoughts from REVIVED chief investigator @divaka_perera and NEJM editorial author @AjayKirtane. doi.org/10.15420/icr.2… #ICRJournal @UKheartresearch @REVIVED_BCIS2 @SabaAssar
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🔴 Effect of PCI on Health Status in Ischemic Left Ventricular Dysfunction: Insights from REVIVED-BCIS2 👉In @REVIVED_BCIS2, PCI did not prolong life in patients with ischemic LV dysfunction. But what about symptoms? jacc.org/doi/10.1016/j.… #CardioEd #Cardiology #CardioTwitter
High quality medical and device therapy remains the cornerstone of treating ischemic heart failure. PCI for symptoms should be for angina, or carefully selected patients with limiting exertional symptoms after optimal titration of medical therapy, with appropriate counselling.
We concluded that patients with ischemic LV dysfunction who undergo PCI have a significant but short-lived improvement in health status. Whilst placebo effect can't be discounted, the gradual "catch-up" in OMT over 2 years suggests against this.
In the secondary analysis, treatment with PCI led to more KCCQ 5-point responders at 6 months, but not at 12 or 24 month follow-up.
In the primary analysis, PCI did not result in better health outcomes analysed using the win ratio at 24 months.
In contrast to previous commentary, baseline health status was severely decreased, with baseline scores lower than those seen in most contemporary #heartfailure trials. PCI led to a substantial initial improvement in KCCQ scores, which persisted to 12 months.
Thanks as always to the @REVIVED_BCIS2 team, collaborators and our patients. @hollymorgs @DrPeterOKane @achir76 @MrTheProf @BSHeartFailure @GSTTresearch @Kings_BHFCentre
The analysis included all patients enrolled in @REVIVED_BCIS2. Health status was ascertained at baseline, 6, 12 and 24 months using the #KCCQ. The primary analysis was a hierarchical win ratio with death, HHF and KCCQ-OSS at 24 months. Secondary outcome was a responder analysis.
In @REVIVED_BCIS2, PCI did not prolong life in patients with ischemic LV dysfunction. But what about symptoms? Our detailed analysis of health status and quality of life out this week in JACC: Heart Failure. jacc.org/doi/10.1016/j.…
Welcome to the @BCIS4Trial X page. This study is funded by the National Institute of Health Research (NIHR) [HTA (NIHR155123]. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care
Sunday 7th April (Berlin) @hollymorgs 1145 (Agora Lecture Rm) Non-invasive electrocardiographic (ECGi) assessment of arrhythmic risk in ischaemic cardiomyopathy patients undergoing revascularisation (@TheBHF ICM-VA study) #EHRA2024 @EHRAPresident @escardio @MedtronicUK
Mon 8th April (Atlanta) @DrMattRyan 0945 (theater 6) Comparative response to anti-ischemic therapy in endotypes of microvascular dysfunction (further analysis of ChaMP-CMD trial doi.org/10.1161/CIRCUL… @AishSinha1) functional CMD compared to structural CMD
Excited to share new research outputs from the group this weekend! @hollymorgs #EHRA2024 @escardio in Berlin @DrMattRyan #acc24 @ACCinTouch in Atlanta @divaka_perera @kingscardio @Kings_BHFCentre
Mon 8th April (Atlanta) @DrMattRyan 0915 (Rm B213) Does LGE predict segmental recovery in severe LVSD? @REVIVED_BCIS2 analysis 1015 (theater 3) Quality of Life after PCI in severe LVSD: a #WinRatio analysis @REVIVED_BCIS2. @JACCJournals @CTU_LSHTM @markcpetrie20 @jspertus
Rationale and design of the CHIP-BCIS3 randomized controlled trial: LV unloading in high-risk PCI. Just published in @circ CVINT. ➡️ historical challenges of trials in MCS ➡️innovative design and ideal population to deliver a definitive trial bit.ly/4bV3VHu
Thanks to our amazing network of @CHIP_BCIS3 @BCIS_uk investigators, trial management group, oversight committees, funders and all the patients who have volunteered, we are firmly on track to complete the trial and answer important questions about LV unloading in high-risk PCI!
Rationale and design of the CHIP-BCIS3 randomized controlled trial: LV unloading in high-risk PCI. Just published in @circ CVINT. ➡️ historical challenges of trials in MCS ➡️innovative design and ideal population to deliver a definitive trial bit.ly/4bV3VHu
❤️Glenfield Hospital, Leicester just recruited one participant more into the EASY-AS study! Congratulations and thank you for your efforts! The trial is becoming a success thanks to you all! 🤩👏 @Leic_hospital @DrAnvesha_Singh @LeicResearch @DrSaadiaAslam @LeicesterCTU
Excellent run through of the Win ratio from the legend that is @TimCClayton, to kick off the #BCISACI "Tik Tok talks" ⏰️ ➡️ Hierarchical end point system, increasingly used in cardiovascular trials including the ongoing @CHIP_BCIS3🫀📈
Comprehensive overview of ischaemic LV dysfunction 👏🏻 Act fast as free access until 27 January! Most downloaded from The PCR-EAPCI 📗 @PCRonline @divaka_perera @DrMattRyan @REVIVED_BCIS2 @BCIS_uk @CHIP_BCIS3 textbooks.pcronline.com/the-pcr-eapci-…