Franziska Thaler @ThalerLab
Neuroimmunologist, clinician scientist investigating the immunobiology of autoimmune encephalitis Joined June 2022-
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Franziska Thaler retweeted
Via @GreenJournal: Researchers have found Class IV evidence of an association between rituximab and a lower hazard to relapse in patients with autoimmune encephalitis: bit.ly/3QcevkB #NeuroTwitter @AANmember
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Franziska Thaler retweeted
In NMDA receptor #encephalitis, patients with persistent CSF NMDAR-Abs at 12 months were more likely to have subsequent relapses and a poor long-term outcome
In NMDA receptor #encephalitis, patients with persistent CSF NMDAR-Abs at 12 months were more likely to have subsequent relapses and a poor long-term outcome
Franziska Thaler retweeted
Don’t miss this excellent updated review: “Autoimmune encephalitis: recent clinical and biological advances” @ANG_Oxford link.springer.com/article/10.100…
Franziska Thaler retweeted
Cytotoxic T cells and plasma cells dominate early in temporal lobe epilepsy with GAD antibodies. New scientific commentary by Franziska Thaler & Edgar Meinl bit.ly/40NP9M6
Franziska Thaler retweeted
Steinke et al. develop and validate a construct that neutralizes autoantibodies from patients with NMDAR encephalitis, and prevents receptor internalization and memory deficits in a mouse model. bit.ly/3Z2vgQi
Franziska Thaler retweeted
Thanks @AAN @GreenJournal N2 for publishing our experience using prolonged corticosteroids for anti-LGI1 encephalitis. Examining the impact of acute immunotherapy regimen on need for maintenance immunotherapy may help optimize our treatment approach. nn.neurology.org/content/10/3/e…
Franziska Thaler retweeted
Congratulations to @LabMader on their new publication! 🥳It was a pleasure to contribute. Take a look at the pathomechanisms of MOG-antibody-associated disease: pnas.org/doi/10.1073/pn…
Happy to share our new manuscript. Many thanks to all co-authors for this great collaboration! @kathieisenhut, @edubeltran_lab, @LabMader, @Ker_Lab, @LabMeinl, @INIM_Munich bit.ly/3Zokjtf
Franziska Thaler retweeted
In a large cohort of patients with anti-IgLON5 disease, Grüter et al. reveal early inflammatory CSF changes, and association of HLA-DRB1*10:01 with higher autoantibody titre, consistent with a primary autoimmune nature of the disease. bit.ly/3kqYn1B
Franziska Thaler retweeted
Study data support the hypothesis that the accumulation of GAD65-specific B cells and plasma cells in the CSF is an important feature of early disease stages of GAD65-Ab spectrum disorders, such as stiff-person syndrome and cerebellar ataxia. Learn more: bit.ly/3Zokjtf
Franziska Thaler retweeted
What happened to #neurological #autoantibody detection rates around the pandemic? We compared 2019 Vs 2020, across the 5 commonest cell surface Abs, and only saw a fall in LGI1 rates. The drop was marked around March-June - the time of the UK lockdown. jamanetwork.com/journals/jaman…
Franziska Thaler retweeted
Check out our new manuscript. Many thanks for this great collaboration: @Samanth68485267, Eva Oswald, Hoi Kiu Wong, @AtayVural, Vuslat Yilmaz, Erdem Tüzün, Recai Türkoğlu, Tobias Straub, Ingrid Meinl, @ThalerLab, Tania Kümpfel @LabMeinl,@LabMader
Check out our new manuscript. Many thanks for this great collaboration: @Samanth68485267, Eva Oswald, Hoi Kiu Wong, @AtayVural, Vuslat Yilmaz, Erdem Tüzün, Recai Türkoğlu, Tobias Straub, Ingrid Meinl, @ThalerLab, Tania Kümpfel @LabMeinl,@LabMader
Franziska Thaler retweeted
Tröscher et al. show that in patients with GAD65 antibody-associated temporal lobe epilepsy, cytotoxic T cells attack and kill neurons and are responsible for the early neuronal loss. bit.ly/3hglZUH
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